| Literature DB >> 17482847 |
Lucio Montebugnoli1, Laura Felicetti, Davide Bartolomeo Gissi, Angelo Pizzigallo, Gian Andrea Pelliccioni, Claudio Marchetti.
Abstract
Sixteen patients with jaw biphosphonate-osteonecrosis and with exposed bone areas were subdivided into 2 treatment groups. The first group (7 patients) underwent superficial or radical surgical therapy, while the second (9 patients) underwent antibiotic treatment. A slight reduction of the necrotic areas was observed in 5 of 7 patients in the first group, whereas no change was observed in the remaining 2 patients at 22- and 24-month follow-up. A slight reduction of the necrotic areas was observed in 7 of 9 patients in the second group, whereas no change was observed in the remaining 2 patients at 5- and 24-month follow-up. The statistical analysis showed that the treatment regimen did not significantly influence the dimensional change in the exposed bone. The preliminary results seem to suggest that biphosphonate-associated osteonecrosis can be well controlled by a nonsurgical protocol consisting in long-term administration of antibiotics.Entities:
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Year: 2007 PMID： 17482847 DOI： 10.1016/j.tripleo.2007.01.008
Source DB: PubMed Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod ISSN： 1079-2104