| Literature DB >> 17482824 |
Isabel Barrachina1, Inmaculada Royo, Héctor A Baldoni, Nadia Chahboune, Fernando Suvire, Nuria DePedro, M Carmen Zafra-Polo, Almudena Bermejo, Noureddine El Aouad, Nuria Cabedo, Jairo Saez, José R Tormo, Ricardo D Enriz, Diego Cortes.
Abstract
We describe herein the isolation and semisynthesis of four acetogenin derivatives (1-4) as well as their ability to inhibit the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound 4, in a fully hydrated POPC bilayer, is reported.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17482824 DOI： 10.1016/j.bmc.2007.04.039
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641