| Literature DB >> 17482642 |
Brad D Barrows1, Joel S Griffitts, Raffi V Aroian.
Abstract
The nematode, Caenorhabditis elegans, can be mutated to resistance to the Cry5B toxin of Bacillus thuringiensis. By cloning and characterization of these C. elegans resistance genes, we have determined that a major mechanism by which C. elegans resists Cry5B is by loss of function mutations in any one of four gylcosyltransferase genes that glycosylate glycolipids specific to arthropods. Without correct gylcosylation, binding of Cry5B is greatly impaired in C. elegans. That these specific arthroseries glycolipids do not occur in vertebrates potentially helps explain why Cry toxins are specific for arthropods.Entities:
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Year: 2007 PMID： 17482642 DOI： 10.1016/j.jip.2007.04.002
Source DB: PubMed Journal: J Invertebr Pathol ISSN： 0022-2011 Impact factor: 2.841