Literature DB >> 17482530

Determination of andrographolide in human plasma by high-performance liquid chromatography/mass spectrometry.

Yanli Gu1, Jinyu Ma, Yali Liu, Bo Chen, Shouzhuo Yao.   

Abstract

In this paper, a rapid method based on high-performance liquid chromatography/electrospray-mass spectrometry (HPLC/ESI-MS) method for the quantitative determination of andrographolide (AND) in human plasma has been developed and validated. A liquid-liquid extraction (LLE) procedure was selected to isolate AND from biological matrixes. Isosorbide-5-mononitrate (IS-5-MN) was selected as the internal standard (IS). The correlation coefficient of the calibration curve was 0.998, in the range of 9.9-320.0 ng/mL. The validated method may be used to assess the bioavailability and pharmacokinetics of the drug.

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Year:  2007        PMID： 17482530     DOI： 10.1016/j.jchromb.2007.03.051

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN： 1570-0232            Impact factor:   3.205


  6 in total

1.  In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities.

Authors:  Yan Pan; Badrul Amini Abd-Rashid; Zakiah Ismail; Rusli Ismail; Joon Wah Mak; Peter C K Pook; Hui Meng Er; Chin Eng Ong
Journal:  J Nat Med       Date:  2011-03-03       Impact factor: 2.343

2.  Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats.

Authors:  Haw-Wen Chen; Chin-Shiu Huang; Pei-Fen Liu; Chien-Chun Li; Chiung-Tong Chen; Cheng-Tzu Liu; Jia-Rong Chiang; Hsien-Tsung Yao; Chong-Kuei Lii
Journal:  Evid Based Complement Alternat Med       Date:  2013-08-12       Impact factor: 2.629

3.  Fabrication and in vitro/in vivo evaluation of amorphous andrographolide nanosuspensions stabilized by d-α-tocopheryl polyethylene glycol 1000 succinate/sodium lauryl sulfate.

Authors:  Hongzhi Qiao; Lihua Chen; Tianqi Rui; Jingxian Wang; Ting Chen; Tingming Fu; Junsong Li; Liuqing Di
Journal:  Int J Nanomedicine       Date:  2017-02-07

4.  Novel nanocrystal-based solid dispersion with high drug loading, enhanced dissolution, and bioavailability of andrographolide.

Authors:  Yueqin Ma; Yang Yang; Jin Xie; Junnan Xu; Pengfei Yue; Ming Yang
Journal:  Int J Nanomedicine       Date:  2018-06-28

5.  Quantitative Determination of Andrographolide and Related Compounds in Andrographis paniculata Extracts and Biological Evaluation of Their Anti-Inflammatory Activity.

Authors:  Emmanuelle Villedieu-Percheron; Véronique Ferreira; Joana Filomena Campos; Emilie Destandau; Chantal Pichon; Sabine Berteina-Raboin
Journal:  Foods       Date:  2019-12-14

6.  Pharmacokinetics and Metabolomic Profiling of Metformin and Andrographis paniculata: A Protocol for a Crossover Randomised Controlled Trial.

Authors:  Khim Boon Tee; Luqman Ibrahim; Najihah Mohd Hashim; Mohd Zuwairi Saiman; Zaril Harza Zakaria; Hasniza Zaman Huri
Journal:  J Clin Med       Date:  2022-07-06       Impact factor: 4.964
  6 in total

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