OBJECTIVES: Our aim was to evaluate the possible association between homocysteine levels and peripheral arterial disease (PAD) in a population-based study of Japanese-Brazilians. MATERIALS AND METHODS: This cross-sectional study was derived from a population-based survey on the prevalence of diabetes and associated diseases conducted in Japanese-Brazilians. A total of 1330 male and female subjects aged>or=30 years were submitted to clinical examination and laboratory procedures including homocysteine measurement. The ankle-brachial index (ABI) was calculated; subjects with ABI values <0.9 were diagnosed with PAD. The evaluable population included 1008 subjects. Logistic regression was used taking PAD as the dependent variable. RESULTS: Mean age of the population was 56.5 years and overall prevalence of PAD was 20%. A worse cardiovascular profile was found in male patients, including significantly higher homocysteine levels (11.9+/-1.8 vs. 9.1+/-1.1micromol/L, p<0.001). Men with PAD had higher prevalence rates of hyperhomocysteinemia compared to women (22.7% vs 7.6%). Univariate analysis showed an odds ratio of hyperhomocysteinemia for PAD of 1.51 [1.02-2.25] in men and 1.69 [1.06-2.68] in women. After adjustment for other cardiovascular risk factors, higher levels of homocysteine were only significantly related to PAD in men. CONCLUSION: In a Japanese-Brazilian population, elevated levels of homocysteine are associated with PAD in men. Prospective studies are necessary to confirm this finding.
OBJECTIVES: Our aim was to evaluate the possible association between homocysteine levels and peripheral arterial disease (PAD) in a population-based study of Japanese-Brazilians. MATERIALS AND METHODS: This cross-sectional study was derived from a population-based survey on the prevalence of diabetes and associated diseases conducted in Japanese-Brazilians. A total of 1330 male and female subjects aged>or=30 years were submitted to clinical examination and laboratory procedures including homocysteine measurement. The ankle-brachial index (ABI) was calculated; subjects with ABI values <0.9 were diagnosed with PAD. The evaluable population included 1008 subjects. Logistic regression was used taking PAD as the dependent variable. RESULTS: Mean age of the population was 56.5 years and overall prevalence of PAD was 20%. A worse cardiovascular profile was found in male patients, including significantly higher homocysteine levels (11.9+/-1.8 vs. 9.1+/-1.1micromol/L, p<0.001). Men with PAD had higher prevalence rates of hyperhomocysteinemia compared to women (22.7% vs 7.6%). Univariate analysis showed an odds ratio of hyperhomocysteinemia for PAD of 1.51 [1.02-2.25] in men and 1.69 [1.06-2.68] in women. After adjustment for other cardiovascular risk factors, higher levels of homocysteine were only significantly related to PAD in men. CONCLUSION: In a Japanese-Brazilian population, elevated levels of homocysteine are associated with PAD in men. Prospective studies are necessary to confirm this finding.
Authors: Adriano Sabino; Ana Paula Fernandes; Luciana Moreira Lima; Daniel Dias Ribeiro; Marinez Oliveira Sousa; Maria Elizabeth Rennó de Castro Santos; Ana Paula Lucas Mota; Luci Maria Sant'Ana Dusse; Maria das Graças Carvalho Journal: J Thromb Thrombolysis Date: 2007-11-27 Impact factor: 2.300
Authors: Maria E R C Santos; Francisco das C L E Silva; Karina B Gomes; Ana Paula M Fernandes; Fernanda R Freitas; Mayara C Faria; Ana Paula L Mota; Maria G Carvalho Journal: Mol Biol Rep Date: 2010-11-23 Impact factor: 2.316
Authors: P G Chiarello; F R O Penaforte; C C Japur; C D A S Souza; H Vannucchi; L E A Troncon Journal: Dig Dis Sci Date: 2008-07-17 Impact factor: 3.199
Authors: Oscar H Del Brutto; Mark J Sedler; Robertino M Mera; Pablo R Castillo; Elizabeth H Cusick; Jadry A Gruen; Kelsie J Phelan; Victor J Del Brutto; Mauricio Zambrano; David L Brown Journal: Int J Vasc Med Date: 2014-09-21