| Literature DB >> 17482463 |
Timothy I Richardson1, Scott A Frank, Minmin Wang, Christian A Clarke, Scott A Jones, Bai-Ping Ying, Dan T Kohlman, Owen B Wallace, Timothy A Shepherd, Robert D Dally, Alan D Palkowitz, Andrew G Geiser, Henry U Bryant, Judith W Henck, Ilene R Cohen, Daniel G Rudmann, Denis J McCann, David E Coutant, Samuel W Oldham, Conrad W Hummel, Kin C Fong, Ronald Hinklin, George Lewis, Hongqi Tian, Jeffrey A Dodge.
Abstract
Structure-activity relationship studies are described, which led to the discovery of novel selective estrogen receptor modulators (SERMs) for the potential treatment of uterine fibroids. The SAR studies focused on limiting brain exposure and were guided by computational properties. Compounds with limited impact on the HPO axis were selected using serum estrogen levels as a biomarker for ovarian stimulation.Entities:
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Year: 2007 PMID： 17482463 DOI： 10.1016/j.bmcl.2007.04.044
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823