| Literature DB >> 17482462 |
Gabor Butora1, Richard Jiao, William H Parsons, Pasquale P Vicario, Hong Jin, Julia M Ayala, Margaret A Cascieri, Lihu Yang.
Abstract
A series of low molecular weight antagonists of both the human and murine CC chemokine receptor 2, containing a 1-alkyl-3-(3-methyl-4-spiroindenylpiperidine)-substituted cyclopentanecarboxamide, is described. A SAR study of the C(1) substituent revealed that short, branched alkyl groups such as isopropyl, isobutyl, or cyclopropyl are optimal for both human and murine CCR2 binding activity.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17482462 DOI： 10.1016/j.bmcl.2007.04.053
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823