| Literature DB >> 17481894 |
Terry V Hughes1, Stuart L Emanuel, Amanda K Beck, Steven K Wetter, Peter J Connolly, Prabha Karnachi, Michael Reuman, Jabed Seraj, Angel R Fuentes-Pesquera, Robert H Gruninger, Steven A Middleton, Ronghui Lin, Jeremy M Davis, David F C Moffat.
Abstract
A novel series of 4-aryl-5-cyano-2-aminopyrimidines were synthesized and found to have potent VEGF-R2 kinase inhibitory activity. Structure-activity relationships were investigated and compound 14a was shown to be efficacious in a mouse model of corneal neovascularization.Entities:
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Year: 2007 PMID： 17481894 DOI： 10.1016/j.bmcl.2007.04.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823