Literature DB >> 17479993

Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease.

Meritxell Egido-Gabás1, Daniel Canals, Josefina Casas, Amadeu Llebaria, Antonio Delgado.   

Abstract

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Year:  2007        PMID： 17479993     DOI： 10.1002/cmdc.200700061

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  6 in total

1.  Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.

Authors:  Samarjit Patnaik; Wei Zheng; Jae H Choi; Omid Motabar; Noel Southall; Wendy Westbroek; Wendy A Lea; Arash Velayati; Ehud Goldin; Ellen Sidransky; William Leister; Juan J Marugan
Journal:  J Med Chem       Date:  2012-06-08       Impact factor: 7.446

2.  Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.

Authors:  Wei Zheng; Janak Padia; Daniel J Urban; Ajit Jadhav; Ozlem Goker-Alpan; Anton Simeonov; Ehud Goldin; Douglas Auld; Mary E LaMarca; James Inglese; Christopher P Austin; Ellen Sidransky
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-01       Impact factor: 11.205

Review 3.  Raising the roof: the preferential pharmacological stimulation of Th1 and th2 responses mediated by NKT cells.

Authors:  James E East; Andrew J Kennedy; Tonya J Webb
Journal:  Med Res Rev       Date:  2012-12-13       Impact factor: 12.944

4.  Non-iminosugar glucocerebrosidase small molecule chaperones.

Authors:  Juan Jose Marugan; Wenwei Huang; Omid Motabar; Wei Zheng; Jingbo Xiao; Samarjit Patnaik; Noel Southall; Wendy Westbroek; Wendy A Lea; Anton Simeonov; Ehud Goldin; Maria A Debernardi; Ellen Sidransky
Journal:  Medchemcomm       Date:  2011-10-24       Impact factor: 3.597

5.  The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease.

Authors:  Ana Trapero; Amadeu Llebaria
Journal:  ACS Med Chem Lett       Date:  2011-05-18       Impact factor: 4.345

6.  Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

Authors:  Juan J Marugan; Wei Zheng; Omid Motabar; Noel Southall; Ehud Goldin; Wendy Westbroek; Barbara K Stubblefield; Ellen Sidransky; Ronald A Aungst; Wendy A Lea; Anton Simeonov; William Leister; Christopher P Austin
Journal:  J Med Chem       Date:  2011-01-20       Impact factor: 7.446
  6 in total

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