Literature DB >> 17479668

Diabetes mellitus is a multivariate independent prognostic factor in endometrial carcinoma: a clinicopathologic study on 313 patients.

E Steiner1, K Plata, C Interthal, M Schmidt, A Faldum, J G Hengstler, N Sakuragi, H Watari, R Yamamoto, H Kölbl.   

Abstract

OBJECTIVE: The aim of this study was to analyse the influence of diabetes mellitus as a prognostic factor for overall survival in endometrial cancer.
MATERIALS AND METHODS: Charts were reviewed from patients with endometrial carcinoma from 1985 to 2003. Data on clinicopathologic variables, adjuvant treatment, site of recurrence and survival were collected. The chi-square test was used to examine associations between variables. The Kaplan-Meier method was used for survival analysis and Cox's proportional hazards model for multiple regression analysis.
RESULTS: Multivariate analysis revealed that diabetes mellitus, FIGO stage and depth of myometrial invasion were significantly associated with overall survival.

Entities:  

Mesh:

Year:  2007        PMID: 17479668

Source DB:  PubMed          Journal:  Eur J Gynaecol Oncol        ISSN: 0392-2936            Impact factor:   0.196


  12 in total

1.  Buformin exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells.

Authors:  Joshua Kilgore; Amanda L Jackson; Leslie H Clark; Hui Guo; Lu Zhang; Hannah M Jones; Timothy P Gilliam; Paola A Gehrig; Chunxiao Zhou; Victoria L Bae-Jump
Journal:  Am J Transl Res       Date:  2016-06-15       Impact factor: 4.060

2.  Reversal of obesity-driven aggressiveness of endometrial cancer by metformin.

Authors:  Hui Guo; Weimin Kong; Lu Zhang; Jianjun Han; Leslie H Clark; Yajie Yin; Ziwei Fang; Wenchuan Sun; Jiandong Wang; Timothy P Gilliam; Douglas Lee; Liza Makowski; Chunxiao Zhou; Victoria L Bae-Jump
Journal:  Am J Cancer Res       Date:  2019-10-01       Impact factor: 6.166

3.  Mononuclear phagocyte system function and nanoparticle pharmacology in obese and normal weight ovarian and endometrial cancer patients.

Authors:  Brittney R Starling; Parag Kumar; Andrew T Lucas; David Barrow; Laura Farnan; Laura Hendrix; Hugh Giovinazzo; Gina Song; Paola Gehrig; Jeannette T Bensen; William C Zamboni
Journal:  Cancer Chemother Pharmacol       Date:  2018-10-16       Impact factor: 3.333

4.  Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway.

Authors:  Rabbie K Hanna; Chunxiao Zhou; Kimberly M Malloy; Li Sun; Yan Zhong; Paola A Gehrig; Victoria L Bae-Jump
Journal:  Gynecol Oncol       Date:  2012-01-16       Impact factor: 5.482

Review 5.  Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis.

Authors:  Bethany B Barone; Hsin-Chieh Yeh; Claire F Snyder; Kimberly S Peairs; Kelly B Stein; Rachel L Derr; Antonio C Wolff; Frederick L Brancati
Journal:  JAMA       Date:  2008-12-17       Impact factor: 56.272

6.  Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy.

Authors:  Leigh A Cantrell; Chunxiao Zhou; Alberto Mendivil; Kimberly M Malloy; Paola A Gehrig; Victoria L Bae-Jump
Journal:  Gynecol Oncol       Date:  2009-10-12       Impact factor: 5.482

7.  Comorbidities and endometrial cancer survival in Hispanics and non-Hispanic whites.

Authors:  Linda S Cook; Harold E Nelson; Myles Cockburn; Sara H Olson; Carolyn Y Muller; Charles L Wiggins
Journal:  Cancer Causes Control       Date:  2012-10-30       Impact factor: 2.506

8.  Novasoy and genistein inhibit endometrial cancer cell proliferation through disruption of the AKT/mTOR and MAPK signaling pathways.

Authors:  Kim M Malloy; Jiandong Wang; Leslie H Clark; Ziwei Fang; Wenchuan Sun; Yajie Yin; Weimin Kong; Chunxiao Zhou; Victoria L Bae-Jump
Journal:  Am J Transl Res       Date:  2018-03-15       Impact factor: 4.060

9.  EDI3, a key enzyme of choline metabolism controls tumour cell migration.

Authors:  Rosemarie Marchan; Joanna D Stewart; Michaela Lesjak
Journal:  EXCLI J       Date:  2012-06-05       Impact factor: 4.068

10.  Regulation of insulin-like growth factor signaling by metformin in endometrial cancer cells.

Authors:  Ya Xie; Jing-Lu Wang; Mei Ji; Zhong-Fu Yuan; Zheng Peng; Yi Zhang; Jian-Guo Wen; Hui-Rong Shi
Journal:  Oncol Lett       Date:  2014-08-20       Impact factor: 2.967

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