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Literature DB >> 17479166

Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones.

Wei Zhang¹, John P Williams, Yimin Lu, Tadamichi Nagashima, Qainli Chu.

Abstract

A new synthetic protocol for sclerotigenin-type benzodiazepine-quinazolinone library scaffold is introduced. A fluorous benzyl protecting group is used for synthesis of 4-benzodiazepine-2,5-dione intermediate and also as a phase tag for fluorous solid-phase extraction (F-SPE).

Entities: Chemical

Year: 2007 PMID： 17479166 PMCID： PMC1865100 DOI： 10.1016/j.tetlet.2006.11.127

Source DB: PubMed Journal: Tetrahedron Lett ISSN： 0040-4039 Impact factor: 2.415

19 in total

1. Solution-phase preparation of a 560-compound library of individual pure mappicine analogues by fluorous mixture synthesis.

Authors: Wei Zhang; Zhiyong Luo; Christine Hiu-Tung Chen; Dennis P Curran
Journal: J Am Chem Soc Date: 2002-09-04 Impact factor: 15.419

2. Microwave-assisted concise total syntheses of quinazolinobenzodiazepine alkaloids.

Authors: Ji-Feng Liu; Mira Kaselj; Yuko Isome; Jennifer Chapnick; Bailin Zhang; Grace Bi; Daniel Yohannes; Libing Yu; Carmen M Baldino
Journal: J Org Chem Date: 2005-12-09 Impact factor: 4.354

3. Benzomalvins, new substance P inhibitors from a Penicillium sp.

Authors: H H Sun; C J Barrow; D M Sedlock; A M Gillum; R Cooper
Journal: J Antibiot (Tokyo) Date: 1994-05 Impact factor: 2.649

Review 4. Fluorous tagging strategy for solution-phase synthesis of small molecules, peptides and oligosaccharides.

Authors: Wei Zhang
Journal: Curr Opin Drug Discov Devel Date: 2004-11

5. Circumdatins D, E, and F: further fungal benzodiazepine analogues from aspergillus ochraceus

Authors:
Journal: J Nat Prod Date: 1999-06 Impact factor: 4.050

6. Fluorous mixture synthesis of two libraries with hydantoin-, and benzodiazepinedione-fused heterocyclic scaffolds.

Authors: Wei Zhang; Yimin Lu; Christine Hiu-Tung Chen; Lu Zeng; Daniel B Kassel
Journal: J Comb Chem Date: 2006 Sep-Oct

Review 7. Recent advances in the solid-phase combinatorial synthetic strategies for the benzodiazepine based privileged structures.

Authors: Ahmed Kamal; K Laxma Reddy; V Devaiah; N Shankaraiah; D Rajasekhar Reddy
Journal: Mini Rev Med Chem Date: 2006-01 Impact factor: 3.862

8. Solution-phase parallel synthesis of an N-alkylated dihydropteridinone library from fluorous amino acids.

Authors: Tadamichi Nagashima; Wei Zhang
Journal: J Comb Chem Date: 2004 Nov-Dec

9. Fluorous synthesis of hydantoins and thiohydantoins.

Authors: Wei Zhang; Yimin Lu
Journal: Org Lett Date: 2003-07-10 Impact factor: 6.005

10. Fluorous Synthesis of Hydantoin-, Piperazinedione-, and Benzodiazepinedione-Fused Tricyclic and Tetracyclic Ring Systems.

Authors: Wei Zhang; Yimin Lu; Christine Hiu-Tung Chen; Dennis P Curran; Steven Geib
Journal: European J Org Chem Date: 2006

2 in total

1. Microwave-assisted fluorous synthesis of a 1,4-benzodiazepine-2,5-dione library.

Authors: Aifeng Liu; Hongyu Zhou; Gaoxing Su; Wei Zhang; Bing Yan
Journal: J Comb Chem Date: 2009 Nov-Dec

2. Fluorous-enhanced multicomponent reactions for making drug-like library scaffolds.

Authors: Wei Zhang
Journal: Comb Chem High Throughput Screen Date: 2007-03 Impact factor: 1.339

2 in total