Literature DB >> 17477310

Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat.

S V S Rana.   

Abstract

Ascorbic acid treatment in arsenic trioxide treated rats increased arsenic excretion, inhibited lipid peroxidation, improved GSH status, regulated GSSG turnover and also restored glutathione-S-transferases activity in liver and kidney. Suitable mechanisms leading to ascorbic acid protection have been discussed. Upregulation of GSH dependent enzymes was found to be necessary for a protective effect. Protection is finally attributed to higher GSH levels observed in the liver and kidney of ascorbic acid and inorganic arsenic treated rats. It is also concluded that ascorbic acid protection is influenced by gender dependent factors. Arsenic poisoning is a global problem now. Gender differences need to be considered while applying therapeutic measures.

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Year:  2007        PMID： 17477310

Source DB:  PubMed          Journal:  Indian J Exp Biol        ISSN： 0019-5189            Impact factor:   0.818


  7 in total

1.  Significance of Inflammation and Apoptosis in Hepatocellular Death in Rat, Co-treated with Arsenic and Fluoride.

Authors:  Huma Khan; Yeshvandra Verma; S V S Rana
Journal:  Biol Trace Elem Res       Date:  2021-11-30       Impact factor: 3.738

2.  Protective effect of naringenin on hepatic and renal dysfunction and oxidative stress in arsenic intoxicated rats.

Authors:  Sam Daniel Mershiba; M Velayutham Dassprakash; Sundara Dhakshinamurthy Saraswathy
Journal:  Mol Biol Rep       Date:  2013-01-03       Impact factor: 2.316

3.  Hepatotoxicity of pentavalent antimonial drug: possible role of residual Sb(III) and protective effect of ascorbic acid.

Authors:  Kelly C Kato; Eliane Morais-Teixeira; Priscila G Reis; Neila M Silva-Barcellos; Pascal Salaün; Paula P Campos; José Dias Corrêa-Junior; Ana Rabello; Cynthia Demicheli; Frédéric Frézard
Journal:  Antimicrob Agents Chemother       Date:  2013-11-04       Impact factor: 5.191

4.  A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice.

Authors:  Afsaneh Nemati; Vahideh Assadollahi; Ilaria Peluso; Abolfazl Abbaszadeh; Mandana Beigi-Boroujeni; Zahra Khanipur; Mohammadreza Gholami
Journal:  Oxid Med Cell Longev       Date:  2020-06-23       Impact factor: 6.543

Review 5.  Recent Advances in Arsenic Research: Significance of Differential Susceptibility and Sustainable Strategies for Mitigation.

Authors:  Tamalika Sanyal; Pritha Bhattacharjee; Somnath Paul; Pritha Bhattacharjee
Journal:  Front Public Health       Date:  2020-10-08

6.  Association of liposome-encapsulated trivalent antimonial with ascorbic acid: an effective and safe strategy in the treatment of experimental visceral leishmaniasis.

Authors:  Renata A O Castro; Neila M Silva-Barcellos; Carolina S A Licio; Janine B Souza; Míriam C Souza-Testasicca; Flávia M Ferreira; Mauricio A Batista; Denise Silveira-Lemos; Sandra L Moura; Frédéric Frézard; Simone A Rezende
Journal:  PLoS One       Date:  2014-08-08       Impact factor: 3.240

7.  Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats.

Authors:  Samir A E Bashandy; Sally A El Awdan; Hossam Ebaid; Ibrahim M Alhazza
Journal:  Oxid Med Cell Longev       Date:  2016-01-13       Impact factor: 6.543
  7 in total

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