Literature DB >> 17476799

[2-C-Methylerythritol phosphate pathway of isoprenoid biosynthesis as a target in identifying of new antibiotics, herbicides, and immunomodulators (Review) ].

Iu V Ershov.   

Abstract

Specific inhibitors of 2-C-methylerythritol phosphate pathway (MEP-pathway), including compounds obtained based on its metabolites, may compose a new class of antibiotics combining high efficiency and low toxicity. MEP-pathway of isoprenoid biosynthesis is a promising target in identifying new herbicides, immunomodulators, and other physiologically active compounds.

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Year:  2007        PMID: 17476799

Source DB:  PubMed          Journal:  Prikl Biokhim Mikrobiol        ISSN: 0555-1099


  6 in total

1.  Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF.

Authors:  Prabagaran Narayanasamy; Hyungjin Eoh; Patrick J Brennan; Dean C Crick
Journal:  Chem Biol       Date:  2010-02-26

2.  Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection.

Authors:  Máire Begley; Peter A Bron; Sinead Heuston; Pat G Casey; Nadine Englert; Jochen Wiesner; Hassan Jomaa; Cormac G M Gahan; Colin Hill
Journal:  Infect Immun       Date:  2008-09-02       Impact factor: 3.441

3.  2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity.

Authors:  J Kipchirchir Bitok; Caren Freel Meyers
Journal:  ACS Chem Biol       Date:  2012-08-06       Impact factor: 5.100

4.  Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q).

Authors:  R Meganathan; Ohsuk Kwon
Journal:  EcoSal Plus       Date:  2009-08

5.  Isolation of 4-hydroxy 3-methyl 2-butenyl 4-diphosphate reductase (ApHDR) gene of methyl erythritol diphosphate (MEP) pathway, in silico analysis and differential tissue specific ApHDR expression in Andrographis paniculata (Burm. f) Nees.

Authors:  Aayeti Shailaja; Mote Srinath; Byreddi Venkata Bhavani Bindu; Charu Chandra Giri
Journal:  Physiol Mol Biol Plants       Date:  2021-02-19

6.  Novel bioassay for the discovery of inhibitors of the 2-C-methyl-D-erythritol 4-phosphate (MEP) and terpenoid pathways leading to carotenoid biosynthesis.

Authors:  Natália Corniani; Edivaldo D Velini; Ferdinando M L Silva; N P Dhammika Nanayakkara; Matthias Witschel; Franck E Dayan
Journal:  PLoS One       Date:  2014-07-31       Impact factor: 3.240

  6 in total

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