E Friberg1, N Orsini, C S Mantzoros, A Wolk. 1. Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, 171 77, Stockholm, Sweden. emilie.friberg@ki.se
Abstract
AIMS/HYPOTHESIS: Diabetes has been associated with a statistically significantly increased risk of endometrial cancer in most, but not all studies. To provide a quantitative assessment of the association between diabetes and risk of endometrial cancer, we conducted a meta-analysis of case-control studies and cohort studies. SUBJECTS AND METHODS: We identified studies by a literature search of PubMed and Embase through to January 2007 and by searching the reference lists of relevant articles. Summary relative risks (RRs) with 95% CIs were calculated using random-effects model. RESULTS: The analysis of diabetes (largely type 2) and endometrial cancer is based on 16 studies (three cohort and 13 case-control studies), including 96,003 participants and 7,596 cases of endometrial cancer. Twelve of the studies showed a statistically significantly increased risk and four a non-significant increased risk of endometrial cancer. In our meta-analysis we found that diabetes was statistically significantly associated with an increased risk of endometrial cancer (summary RR 2.10, 95% CI 1.75-2.53). The risk estimates were somewhat stronger among case-control (RR 2.22, 95% CI 1.80-2.74) than among cohort studies (RR 1.62, 95% CI 1.21-2.16), stronger among studies adjusting only for age (RR 2.74, 95% CI 1.87-4.00) compared with multivariate adjustment (RR 1.92, 95% CI 1.58-2.33) and slightly lower in studies performed in the USA than in those performed Europe. The analysis of type 1 diabetes and endometrial cancer was based on three studies and found a statistically significant positive association (summary RR 3.15, 95%CI 1.07-9.29). CONCLUSIONS/ INTERPRETATION: Results from the meta-analysis support a relationship between diabetes and increased risk of endometrial cancer.
AIMS/HYPOTHESIS: Diabetes has been associated with a statistically significantly increased risk of endometrial cancer in most, but not all studies. To provide a quantitative assessment of the association between diabetes and risk of endometrial cancer, we conducted a meta-analysis of case-control studies and cohort studies. SUBJECTS AND METHODS: We identified studies by a literature search of PubMed and Embase through to January 2007 and by searching the reference lists of relevant articles. Summary relative risks (RRs) with 95% CIs were calculated using random-effects model. RESULTS: The analysis of diabetes (largely type 2) and endometrial cancer is based on 16 studies (three cohort and 13 case-control studies), including 96,003 participants and 7,596 cases of endometrial cancer. Twelve of the studies showed a statistically significantly increased risk and four a non-significant increased risk of endometrial cancer. In our meta-analysis we found that diabetes was statistically significantly associated with an increased risk of endometrial cancer (summary RR 2.10, 95% CI 1.75-2.53). The risk estimates were somewhat stronger among case-control (RR 2.22, 95% CI 1.80-2.74) than among cohort studies (RR 1.62, 95% CI 1.21-2.16), stronger among studies adjusting only for age (RR 2.74, 95% CI 1.87-4.00) compared with multivariate adjustment (RR 1.92, 95% CI 1.58-2.33) and slightly lower in studies performed in the USA than in those performed Europe. The analysis of type 1 diabetes and endometrial cancer was based on three studies and found a statistically significant positive association (summary RR 3.15, 95%CI 1.07-9.29). CONCLUSIONS/ INTERPRETATION: Results from the meta-analysis support a relationship between diabetes and increased risk of endometrial cancer.
Authors: E Salazar-Martínez; E C Lazcano-Ponce; G G Lira-Lira; P Escudero-De los Rios; J Salmerón-Castro; F Larrea; M Hernández-Avila Journal: Cancer Causes Control Date: 2000-09 Impact factor: 2.506
Authors: Jocelyn M Weiss; Babette S Saltzman; Jennifer A Doherty; Lynda F Voigt; Chu Chen; Shirley A A Beresford; Deirdre A Hill; Noel S Weiss Journal: Am J Epidemiol Date: 2006-05-04 Impact factor: 4.897
Authors: Steven S Coughlin; Eugenia E Calle; Lauren R Teras; Jennifer Petrelli; Michael J Thun Journal: Am J Epidemiol Date: 2004-06-15 Impact factor: 4.897
Authors: Corinne E Joshu; Anna E Prizment; Paul J Dluzniewski; Andy Menke; Aaron R Folsom; Josef Coresh; Hsin C Yeh; Frederick L Brancati; Elizabeth A Platz; Elizabeth Selvin Journal: Int J Cancer Date: 2012-02-10 Impact factor: 7.396
Authors: Lola B Chambless; Scott L Parker; Laila Hassam-Malani; Matthew J McGirt; Reid C Thompson Journal: J Neurooncol Date: 2011-08-11 Impact factor: 4.130
Authors: Parul Sinha; Mitra Mehrad; Rebecca D Chernock; James S Lewis; Samir K El-Mofty; Ningying Wu; Brian Nussenbaum; Bruce H Haughey Journal: Head Neck Date: 2014-01-16 Impact factor: 3.147
Authors: Jae Moon Yoon; Ki Young Son; Chun Sick Eom; Daniel Durrance; Sang Min Park Journal: World J Gastroenterol Date: 2013-02-14 Impact factor: 5.742