| Literature DB >> 17475243 |
Xiaojian Xu1, Haisu Guo, Diane L Wycuff, Myeongwoo Lee.
Abstract
During Caenorhabditis elegans ovulation, the somatic gonad integrates signals from germ cells and propels a mature oocyte into the spermatheca for fertilization. Previous work suggests that phosphoinositide signaling plays important roles in C. elegans fertility. To fully understand inositol-1,4,5-trisphosphate (IP(3)) signaling in ovulation, we have examined the function of phosphatidylinositol-4-phosphate 5' kinase (PIP5K) in C. elegans. Our results show that the C. elegans PIP5K homolog, ppk-1, is essential for ovulation in C. elegans; ppk-1 is mainly expressed in somatic gonad, and depletion of ppk-1 expression causes defective ovulation, reduced gonad sheath contractility, and sterility. Increased IP(3) signaling compensates for ppk-1 (RNAi)-induced sterility, suggesting that ppk-1 is linked to IP(3) signaling. These results demonstrate that ppk-1 plays an essential role in IP(3) signaling and cytoskeleton organization in somatic gonad.Entities:
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Year: 2007 PMID： 17475243 PMCID： PMC1950138 DOI： 10.1016/j.yexcr.2007.03.017
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905