Literature DB >> 17474733

Molecular reaction mechanisms of combination treatments of low-dose cisplatin with radiotherapy and photodynamic therapy.

Q-B Lu1.   

Abstract

Combination of low-dose cisplatin with radiotherapy or photodynamic therapy (PDT) is a novel cancer treatment. Using time-resolved femtosecond laser spectroscopy, we reveal the molecular mechanisms of the combinations of cisplatin with radiotherapy and PDT using indocyanine green (ICG) excited at 800 nm. DNA damage measurements confirm that electron-transfer reactions of cisplatin with electrons generated in ionizing radiation and with the ICG singlet excited state in PDT are responsible for the cytotoxic enhancements.

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Year:  2007        PMID： 17474733     DOI： 10.1021/jm061416b

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  14 in total

1.  Non-empirical quantum chemical studies on electron transfer reactions in trans- and cis-diamminedichloroplatinum(II) complexes.

Authors:  Janina Kuduk-Jaworska; Henryk Chojnacki; Jerzy J Jański
Journal:  J Mol Model       Date:  2011-05-11       Impact factor: 1.810

2.  Direct observation of ultrafast-electron-transfer reactions unravels high effectiveness of reductive DNA damage.

Authors:  Jenny Nguyen; Yuhan Ma; Ting Luo; Robert G Bristow; David A Jaffray; Qing-Bin Lu
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-05       Impact factor: 11.205

3.  Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical, and lung cancers.

Authors:  Ting Luo; Jianqing Yu; Jenny Nguyen; Chun-Rong Wang; Robert G Bristow; David A Jaffray; Xiao Zhen Zhou; Kun Ping Lu; Qing-Bin Lu
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-08       Impact factor: 11.205

4.  Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells?

Authors:  Fang-Zhen Shen; Jing Wang; Jun Liang; Kun Mu; Ji-Yuan Hou; Yan-Tao Wang
Journal:  Int J Exp Pathol       Date:  2010-02       Impact factor: 1.925

5.  New insights into the mechanism underlying the synergistic action of ionizing radiation with platinum chemotherapeutic drugs: the role of low-energy electrons.

Authors:  Mohammad Rezaee; Darel John Hunting; Léon Sanche
Journal:  Int J Radiat Oncol Biol Phys       Date:  2013-08-01       Impact factor: 7.038

6.  In vitro and in vivo study of a nanoliposomal cisplatin as a radiosensitizer.

Authors:  Xiaomeng Zhang; Huanjun Yang; Ke Gu; Jian Chen; Mengjie Rui; Guo-Liang Jiang
Journal:  Int J Nanomedicine       Date:  2011-02-21

7.  In Vitro and In Vivo Studies of Non-Platinum-Based Halogenated Compounds as Potent Antitumor Agents for Natural Targeted Chemotherapy of Cancers.

Authors:  Qing-Bin Lu; Qin-Rong Zhang; Ning Ou; Chun-Rong Wang; Jenny Warrington
Journal:  EBioMedicine       Date:  2015-04-20       Impact factor: 8.143

8.  Antioxidant induces DNA damage, cell death and mutagenicity in human lung and skin normal cells.

Authors:  Linda Y Lu; Ning Ou; Qing-Bin Lu
Journal:  Sci Rep       Date:  2013-11-08       Impact factor: 4.379

9.  Combination of Near Infrared Light-Activated Photodynamic Therapy Mediated by Indocyanine Green with Etoposide to Treat Non-Small-Cell Lung Cancer.

Authors:  Ting Luo; Qinrong Zhang; Qing-Bin Lu
Journal:  Cancers (Basel)       Date:  2017-06-05       Impact factor: 6.639

10.  Sensitive Marker of the Cisplatin-DNA Interaction: X-Ray Photoelectron Spectroscopy of CL.

Authors:  Fangxing Xiao; Xiaobin Yao; Qianhong Bao; Danzhen Li; Yi Zheng
Journal:  Bioinorg Chem Appl       Date:  2012-10-24       Impact factor: 7.778
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