| Literature DB >> 17474115 |
Naoki Sakata1, Naomi Toguchi, Masatomo Kimura, Masahiro Nakayama, Keisei Kawa, Tsukasa Takemura.
Abstract
Chronic active Epstein-Barr virus (CAEBV) infection is characterized by a status of lymphoproliferative disease of EBV-infected cells, resulting in chronic or recurrent infectious mononucleosis-like symptoms. CAEBV is always accompanied by life-threatening complications. We report the case of a 2-year-old female patient with CAEBV who subsequently developed Langerhans cell histiocytosis (LCH) presenting with bilateral exophthalmos, bone, and skin involvement. In situ hybridization for EBER revealed EBV-infected B-cells present in lesional tissue implying that interactions between EBV-infected B-cells and lesional Langerhans cells may be associated with the development of LCH. (c) 2008 Wiley-Liss, Inc.Entities:
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Year: 2008 PMID: 17474115 DOI: 10.1002/pbc.21249
Source DB: PubMed Journal: Pediatr Blood Cancer ISSN: 1545-5009 Impact factor: 3.167