Literature DB >> 174740

Regulation in vitro of rat liver pyruvate kinase by phosphorylation-dephosphorylation reactions, catalyzed by cyclic-AMP dependent protein kinases and a histone phosphatase.

V P Titanji, O Zetterqvist, L Engstroöm.   

Abstract

1. Cyclic-AMP dependent protein kinases, resolved by chromatography on DEAE-cellulose and hydroxylapatite, catalysed the phosphorylation of rat liver pyruvate kinase and calf thymus histones by [gamma32P]ATP. [32P]phosphopeptides, from acid hydrolysates of pyruvate kinase phosphorylated by the different protein kinase fractions, displayed identical electrophoretic patterns. Phosphorylation inhibited pyruvate kinase activity. 2. Full activity was restored when phosphorylated pyruvate kinase was dephosphorylated by a histone phosphatase from the soluble fraction of rat liver. These results are consistent with the hypothesis that pyruvate kinase is regulated by phosphorylation-dephosphorylation reactions.

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Year:  1976        PMID： 174740     DOI： 10.1016/0005-2744(76)90011-5

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  12 in total

1.  In vivo and in vitro phosphorylation of rat liver fructose-1,6-bisphosphatase.

Authors:  J P Riou; T H Claus; D A Flockhart; J D Corbin; S J Pilkis
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

2.  A study of regulation of gluconeogenesis and the supply of cytosolic reducing equivalents for lactate formation in rat kidney-cortical-tubule fragments incubated with pyruvate.

Authors:  E D Saggerson
Journal:  Biochem J       Date:  1978-07-15       Impact factor: 3.857

3.  Purification and characterization of skeletal muscle pyruvate kinase from the hibernating ground squirrel, Urocitellus richardsonii: potential regulation by posttranslational modification during torpor.

Authors:  Ryan A V Bell; Kenneth B Storey
Journal:  Mol Cell Biochem       Date:  2017-09-16       Impact factor: 3.396

4.  Studies on the biosynthesis of hepatic pyruvate kinase and its correlation with enhanced hepatic lipogenesis in meal-trained rats.

Authors:  T J Hopkirk; D P Bloxham
Journal:  Biochem J       Date:  1979-08-15       Impact factor: 3.857

5.  Dietary P(i) deprivation in rats affects liver cAMP, glycogen, key steps of gluconeogenesis and glucose production.

Authors:  W Xie; T L Tran; D T Finegood; G van de Werve
Journal:  Biochem J       Date:  2000-11-15       Impact factor: 3.857

6.  Development of gluconeogenesis from dihydroxyacetone in rat hepatocytes during a feeding cycle and starvation.

Authors:  B Azzout; J Peret
Journal:  Biochem J       Date:  1984-03-15       Impact factor: 3.857

7.  Long-term modulation of type L pyruvate kinase activity in young and mature rats.

Authors:  M E James; J B Blair
Journal:  Biochem J       Date:  1982-04-15       Impact factor: 3.857

8.  Purification and Regulation of Pyruvate Kinase from the Foot Muscle of the Anoxia and Freeze Tolerant Marine Snail, Littorina littorea.

Authors:  Michael B Smolinski; Anchal Varma; Stuart R Green; Kenneth B Storey
Journal:  Protein J       Date:  2020-10-23       Impact factor: 2.371

9.  Hormonal regulation of L-type pyruvate kinase in hepatocytes from phosphorylase kinase-deficient (gsd/gsd) rats.

Authors:  M G Clark; G S Patten; D G Clark
Journal:  Biochem J       Date:  1984-12-15       Impact factor: 3.857

10.  Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes.

Authors:  J E Feliú; L Hue; H G Hers
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205
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