OBJECTIVES: The goal of this study was to characterize differences in survival between black patients and white patients with squamous cell carcinoma of the head and neck (HNSCCA). DESIGN: Cases of oral tongue and glottic SCCA in black patients or white patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database (years 1988-2002). For each primary site, TNM staging was imputed, and staging distributions were compared between races. For each black patient, a randomly selected white control was matched for age at diagnosis, sex, stage, surgical treatment, and radiation. Kaplan-Meier survival comparisons for both overall and disease-specific survival were then conducted for the matched pairs. RESULTS: From 1,919 cases of carcinoma of the oral tongue, those of 151 black and 1,768 white patients were extracted. Black patients had a significantly elevated T stage (P = .001) and N stage (P = .002) at primary presentation. Of glottic carcinoma, 4,578 cases (625 black and 3,953 white patients) were extracted. Black patients again presented with significantly elevated T stage (P < .001) and N stage (P < .001) compared with white patients. For 43 matched pairs with tongue carcinoma, mean overall survival for black patients was 66.1 months versus 74.8 months for matched white controls (P = .502, log-rank test). Disease-specific survival was 91.1 months for black patients versus 109.6 months for white patients (P = .168). For 401 matched pairs with glottic carcinoma, mean overall survival for black patients was 96.6 months versus 114.5 months for white controls (P < .001). Similarly, the mean disease-specific survival was 149.4 months for black patients versus 167.1 months for white patients (P < .001) CONCLUSION: Controlling for stage and treatment, black patients demonstrate poorer overall and disease-specific survival with SCCA, implying other intrinsic or extrinsic factors influencing survival.
OBJECTIVES: The goal of this study was to characterize differences in survival between black patients and white patients with squamous cell carcinoma of the head and neck (HNSCCA). DESIGN: Cases of oral tongue and glottic SCCA in black patients or white patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database (years 1988-2002). For each primary site, TNM staging was imputed, and staging distributions were compared between races. For each black patient, a randomly selected white control was matched for age at diagnosis, sex, stage, surgical treatment, and radiation. Kaplan-Meier survival comparisons for both overall and disease-specific survival were then conducted for the matched pairs. RESULTS: From 1,919 cases of carcinoma of the oral tongue, those of 151 black and 1,768 white patients were extracted. Black patients had a significantly elevated T stage (P = .001) and N stage (P = .002) at primary presentation. Of glottic carcinoma, 4,578 cases (625 black and 3,953 white patients) were extracted. Black patients again presented with significantly elevated T stage (P < .001) and N stage (P < .001) compared with white patients. For 43 matched pairs with tongue carcinoma, mean overall survival for black patients was 66.1 months versus 74.8 months for matched white controls (P = .502, log-rank test). Disease-specific survival was 91.1 months for black patients versus 109.6 months for white patients (P = .168). For 401 matched pairs with glottic carcinoma, mean overall survival for black patients was 96.6 months versus 114.5 months for white controls (P < .001). Similarly, the mean disease-specific survival was 149.4 months for black patients versus 167.1 months for white patients (P < .001) CONCLUSION: Controlling for stage and treatment, black patients demonstrate poorer overall and disease-specific survival with SCCA, implying other intrinsic or extrinsic factors influencing survival.
Authors: Gene-Fu F Liu; Mark C Ranck; Abhishek A Solanki; Hongyuan Cao; Antonia Kolokythas; Barry L Wenig; Lucy Chen; Stephanie Ard; Ralph R Weichselbaum; Howard Halpern; Michael T Spiotto Journal: Cancer Date: 2013-10-10 Impact factor: 6.860
Authors: Hugh A J Kim; Peter Y F Zeng; Alana Sorgini; Mushfiq H Shaikh; Halema Khan; Danielle MacNeil; Mohammed I Khan; Adrian Mendez; John Yoo; Kevin Fung; Pencilla Lang; David A Palma; Joe S Mymryk; John W Barrett; Krupal B Patel; Paul C Boutros; Anthony C Nichols Journal: Head Neck Date: 2022-02-21 Impact factor: 3.821
Authors: Bryce B Reeve; Jianwen Cai; Hongtao Zhang; Jaeun Choi; Mark C Weissler; David Cella; Andrew F Olshan Journal: Head Neck Date: 2012-08-21 Impact factor: 3.147
Authors: Joseph L Russell; Nai-Wei Chen; Shani J Ortiz; Travis P Schrank; Yong-Fang Kuo; Vicente A Resto Journal: JAMA Otolaryngol Head Neck Surg Date: 2014-06 Impact factor: 6.223
Authors: Leon M Chen; Guojun Li; Lorraine R Reitzel; Kristen B Pytynia; Mark E Zafereo; Qingyi Wei; Erich M Sturgis Journal: Cancer Prev Res (Phila) Date: 2009-09-08