Literature DB >> 174733

A putative glucocorticoid receptor and a transcortin-like macromolecule in pituitary cytosol.

E R De Kloet, B S McEwen.   

Abstract

This study describes the binding of [3H]corticosterone and [3H] dexamethasone to soluble macromolecules in the pituitaries of adrenalectomized rats perfused at sacrifice to remove blood contamination. (1) Unlabeled dexamethasone competes only slightly for [3H] corticosterone binding when the steroids are added to cytosol as well as when the steroids are present from the time of disruption of the tissue. In the latter case, corticosterone is as good a competitor as dexamethasone for [3H]dexamethasone binding. (2) Gel permeation chrmatography with BioRad A-5M reveals the presence of a [3H] corticosterone-macromolecular complex with an elution volume comparable to transcortin as well as a very large hormone-binding complex eluting in the void volume of the column...

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Year:  1976        PMID： 174733     DOI： 10.1016/0304-4165(76)90175-6

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

1.  Autoradiographic studies of 3H-dexamethasone uptake by immunocytochemically characterized cells of the rat pituitary.

Authors:  H D Rees; W E Stumpf; M Sar; P Petrusz
Journal:  Cell Tissue Res       Date:  1977-08-26       Impact factor: 5.249

2.  Specific binding of human corticosteroid-binding globulin to cell membranes.

Authors:  D J Hryb; M S Khan; N A Romas; W Rosner
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

3.  Expression of corticosteroid-binding globulin in human astrocytoma cell line.

Authors:  Larissa Pusch; Sonja Wegmann; Jack D Caldwell; Gustav F Jirikowski
Journal:  Cell Mol Neurobiol       Date:  2009-01-27       Impact factor: 5.046

4.  Autoradiographic localization of 3H-glucocorticoids and 3H-cortexolone in mouse pituitary.

Authors:  M Coutard; M J Osborne-Pellegrin; J Funder
Journal:  Cell Tissue Res       Date:  1979-08       Impact factor: 5.249

5.  Rat anterior pituitary. Distinction of an approximately 8S, corticosterone-preferring species from dexamethasone-binding glucocorticoid receptors.

Authors:  Z S Krozowski; J W Funder
Journal:  J Clin Invest       Date:  1982-10       Impact factor: 14.808

6.  Effects of extrahypothalamic structures on the hypothalamic cell nuclear binding of corticosterone.

Authors:  J Weidenfeld; I Chowers; N Conforti; S Feldman
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972

7.  Receptor binding of corticosterone in some rat brain structures following neonatal blockade of the hypophyseoadrenal system.

Authors:  I A Garina; D A Zhukov; V V Rakitskaya; V G Shalyapina
Journal:  Neurosci Behav Physiol       Date:  1986 Sep-Oct

8.  Synthesis and secretion of corticosteroid-binding globulin by rat liver. A source of heterogeneity of hepatic corticosteroid-binders.

Authors:  J N Weiser; Y S Do; D Feldman
Journal:  J Clin Invest       Date:  1979-03       Impact factor: 14.808

9.  Rapid glucocorticoid inhibition of vasoactive intestinal peptide-induced cyclic AMP accumulation and prolactin release in rat pituitary cells in culture.

Authors:  W H Rotsztejn; M Dussaillant; F Nobou; G Rosselin
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

10.  A rapid release of corticosteroid-binding globulin from the liver restrains the glucocorticoid hormone response to acute stress.

Authors:  Xiaoxiao Qian; Susanne K Droste; María Gutièrrez-Mecinas; Andrew Collins; Flavie Kersanté; Johannes M H M Reul; Astrid C E Linthorst
Journal:  Endocrinology       Date:  2011-08-09       Impact factor: 4.736
  10 in total

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