AIMS: To distinguish the most sensitive markers of methylphenidate (MPH) effects on behavior and underlying biology using an integrated cognitive and brain function test battery. METHODS: A randomized placebo-controlled trial with 32 healthy adult males. Subjects were tested on MPH doses across 18 sessions with subjective mood, objective behavioral and biological endpoints. From a computerized battery of tests, behavioral measures were cognitive performance scores, while biological measures of brain function included electroencephalographs (EEG) and event-related potentials (ERPs) with complementary measures of autonomic arousal. Using mixed modeling analyses; we determined which measures were most affected by MPH dose and correlation analyses determined the associations among them. RESULTS: MPH dose had the most pronounced effect on cognitive performance (sustained attention/vigilance), baseline autonomic arousal (heart rate, blood pressure) and baseline brain activity (EEG theta power). The faster reaction time, reduced errors, increased autonomic arousal and reductions in theta showed strong to moderate inter-correlations. MPH least affected subjective mood measures and early sensory ERP components. DISCUSSION: These findings suggest that MPH increases cortical and autonomic arousal, facilitating vigilance. The combination of behavioral and biological measures may provide an objective set of markers of MPH response. INTEGRATIVE SIGNIFICANCE: This approach has provided additional insight into the mechanism of the stimulant medication, MPH, which would not be achieved by using such measures in isolation.
RCT Entities:
AIMS: To distinguish the most sensitive markers of methylphenidate (MPH) effects on behavior and underlying biology using an integrated cognitive and brain function test battery. METHODS: A randomized placebo-controlled trial with 32 healthy adult males. Subjects were tested on MPH doses across 18 sessions with subjective mood, objective behavioral and biological endpoints. From a computerized battery of tests, behavioral measures were cognitive performance scores, while biological measures of brain function included electroencephalographs (EEG) and event-related potentials (ERPs) with complementary measures of autonomic arousal. Using mixed modeling analyses; we determined which measures were most affected by MPH dose and correlation analyses determined the associations among them. RESULTS: MPH dose had the most pronounced effect on cognitive performance (sustained attention/vigilance), baseline autonomic arousal (heart rate, blood pressure) and baseline brain activity (EEG theta power). The faster reaction time, reduced errors, increased autonomic arousal and reductions in theta showed strong to moderate inter-correlations. MPH least affected subjective mood measures and early sensory ERP components. DISCUSSION: These findings suggest that MPH increases cortical and autonomic arousal, facilitating vigilance. The combination of behavioral and biological measures may provide an objective set of markers of MPH response. INTEGRATIVE SIGNIFICANCE: This approach has provided additional insight into the mechanism of the stimulant medication, MPH, which would not be achieved by using such measures in isolation.
Authors: David A MacQueen; Arpi Minassian; Johnny A Kenton; Mark A Geyer; William Perry; Jonathan L Brigman; Jared W Young Journal: Neuropharmacology Date: 2018-05-31 Impact factor: 5.250
Authors: Anke M W Linssen; Eric F P M Vuurman; Anke Sambeth; Stephane Nave; Will Spooren; Gabriel Vargas; Luca Santarelli; Wim J Riedel Journal: Psychopharmacology (Berl) Date: 2011-05-20 Impact factor: 4.530
Authors: Jean-Luc Mommaerts; Gerlinde Beerens; Lieve Van den Block; Eric Soetens; Sandrina Schol; Erwin Van De Vijver; Dirk Devroey Journal: Psychol Res Behav Manag Date: 2013-08-27
Authors: Desirée B Spronk; Marieke E Van der Schaaf; Roshan Cools; Ellen R A De Bruijn; Barbara Franke; Janelle H P van Wel; Johannes G Ramaekers; Robbert J Verkes Journal: Psychopharmacology (Berl) Date: 2015-11-17 Impact factor: 4.530
Authors: Kristi R Griffiths; Barbora G Jurigova; John E Leikauf; Donna Palmer; Simon D Clarke; Tracey W Tsang; Erdahl T Teber; Michael R Kohn; Leanne M Williams Journal: J Atten Disord Date: 2017-10-03 Impact factor: 3.256