BACKGROUND: Cognitive difficulties are prevalent in people with a diagnosis of schizophrenia and are associated with poor long-term functioning. AIMS: To evaluate the effectiveness of cognitive remediation therapy on cognitive difficulties experienced by people with schizophrenia. METHOD:Participants with a diagnosis of schizophrenia, a social behaviour problem and a cognitive difficulty (n=85) were randomised to 40 sessions of cognitive remediation or treatment as usual in a single-blind randomised controlled trial. Working memory, cognitive flexibility and planning, were measured at weeks 0,14 and 40. RESULTS: There were durable improvements in working memory (advantage 1.33 points, 95% CI 0.43-2.16, standardised effect size 0.34) as well as an indication of improvement in cognitive flexibility. Memory improvement predicted improvement in social functioning. Costs were lower in the cognitive remediation group following therapy but rose at follow-up. However, cost-effectiveness analyses showed that improvements in memory were achieved at little additional cost. CONCLUSIONS:Cognitive remediation therapy is associated with durable improvements in memory, which in turn are associated with social functioning improvements in people with severe mental illness.
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BACKGROUND: Cognitive difficulties are prevalent in people with a diagnosis of schizophrenia and are associated with poor long-term functioning. AIMS: To evaluate the effectiveness of cognitive remediation therapy on cognitive difficulties experienced by people with schizophrenia. METHOD:Participants with a diagnosis of schizophrenia, a social behaviour problem and a cognitive difficulty (n=85) were randomised to 40 sessions of cognitive remediation or treatment as usual in a single-blind randomised controlled trial. Working memory, cognitive flexibility and planning, were measured at weeks 0,14 and 40. RESULTS: There were durable improvements in working memory (advantage 1.33 points, 95% CI 0.43-2.16, standardised effect size 0.34) as well as an indication of improvement in cognitive flexibility. Memory improvement predicted improvement in social functioning. Costs were lower in the cognitive remediation group following therapy but rose at follow-up. However, cost-effectiveness analyses showed that improvements in memory were achieved at little additional cost. CONCLUSIONS: Cognitive remediation therapy is associated with durable improvements in memory, which in turn are associated with social functioning improvements in people with severe mental illness.
Authors: Triptish Bhatia; Akhilesh Agarwal; Gyandeepak Shah; Joel Wood; Jan Richard; Raquel E Gur; Ruben C Gur; Vishwajit L Nimgaonkar; Sati Mazumdar; Smita N Deshpande Journal: Acta Neuropsychiatr Date: 2011-08-10 Impact factor: 3.403
Authors: Elizabeth A Cook; Nancy H Liu; Melissa Tarasenko; Charlie A Davidson; William D Spaulding Journal: J Nerv Ment Dis Date: 2013-09 Impact factor: 2.254
Authors: Keith H Nuechterlein; Joseph Ventura; Kenneth L Subotnik; Jacqueline N Hayata; Alice Medalia; Morris D Bell Journal: Am J Psychiatr Rehabil Date: 2014-07
Authors: Tatiana L Taylor; Helen Killaspy; Christine Wright; Penny Turton; Sarah White; Thomas W Kallert; Mirjam Schuster; Jorge A Cervilla; Paulette Brangier; Jiri Raboch; Lucie Kalisová; Georgi Onchev; Hristo Dimitrov; Roberto Mezzina; Kinou Wolf; Durk Wiersma; Ellen Visser; Andrzej Kiejna; Patryk Piotrowski; Dimitri Ploumpidis; Fragiskos Gonidakis; José Caldas-de-Almeida; Graça Cardoso; Michael B King Journal: BMC Psychiatry Date: 2009-09-07 Impact factor: 3.630