Essi Viding1, Paul J Frick, Robert Plomin. 1. Social Genetic and Developmental Psychiatry Centre, P080, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. e.viding@iop.kcl.ac.uk.
Abstract
BACKGROUND: A callous and unemotional disposition is an indicator of early-onset antisocial behaviour. AIMS: To investigate the extent to which genetic influences contribute to the overlap between callous-unemotional traits and conduct problems in a large population sample of 7-year-old twins. METHOD: Teachers provided ratings of callous-unemotional traits and conduct problems for 3434 twin pairs from the Twins Early Development Study. Model-fitting analyses were performed across the continuum of scores and at the extremes. RESULTS: The phenotypic relationship was primarily genetically mediated, both across the continuum and at the extremes and was substantial. CONCLUSIONS: At 7 years of age, genetic influences on callous-unemotional traits overlap substantially with genetic influences on conduct problems. This combination should guide selection criteria in future molecular genetic studies.
BACKGROUND: A callous and unemotional disposition is an indicator of early-onset antisocial behaviour. AIMS: To investigate the extent to which genetic influences contribute to the overlap between callous-unemotional traits and conduct problems in a large population sample of 7-year-old twins. METHOD: Teachers provided ratings of callous-unemotional traits and conduct problems for 3434 twin pairs from the Twins Early Development Study. Model-fitting analyses were performed across the continuum of scores and at the extremes. RESULTS: The phenotypic relationship was primarily genetically mediated, both across the continuum and at the extremes and was substantial. CONCLUSIONS: At 7 years of age, genetic influences on callous-unemotional traits overlap substantially with genetic influences on conduct problems. This combination should guide selection criteria in future molecular genetic studies.
Authors: Dennis E Reidy; Elizabeth Krusemark; David S Kosson; Megan C Kearns; Joanne Smith-Darden; Kent A Kiehl Journal: Child Psychiatry Hum Dev Date: 2017-12