Literature DB >> 174708

The activities of some polycyclic hydrocarbons and their "K region" epoxides in an in vitro-in vivo carcinogenicity test system.

A Flaks, P Sims.   

Abstract

Benz(a)anthracene, 7,12-dimethylbenz(a)anthracene, dibenz(a)anthracene and benzo(a)pyrene and their related "K region" epoxides were tested for carcinogenic activities using a system in which mouse lung tissue was incubated in the presence of the test compound for 30 min and then implanted into isologous mice. Only 7,12-dimethylbenz(a)anthracene showed any marked carcinogenic activity under the conditions used, but all the compounds tested produced extensive proliferative outgrowths in the implanted tissues that may represent specific responses to the carcinogens.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 174708      PMCID： PMC2024801          DOI： 10.1038/bjc.1975.267

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  31 in total

1.  IN VITRO CELL TRANSFORMATION WITH CHEMICAL CARCINOGENS.

Authors:  Y BERWALD; L SACHS
Journal:  Nature       Date:  1963-12-21       Impact factor: 49.962

2.  Ultrastructure of pulmonary adenomas in mice.

Authors:  D J SVOBODA
Journal:  Cancer Res       Date:  1962-11       Impact factor: 12.701

3.  A modified technique for organ culture in vitro.

Authors:  O A TROWELL
Journal:  Exp Cell Res       Date:  1954-02       Impact factor: 3.905

4.  Transformation of hamster embryo cells by epoxides and other derivatives of polycyclic hydrocarbons.

Authors:  E Huberman; T Kuroki; H Marquardt; J K Selkirk; C Heidelberger; P L Grover; P Sims
Journal:  Cancer Res       Date:  1972-07       Impact factor: 12.701

5.  The carcinogenic activities in mice of compounds related to 3-methylcholanthrene.

Authors:  P Sims
Journal:  Int J Cancer       Date:  1967-09-15       Impact factor: 7.396

6.  The metabolism of benz[a]anthracene and dibenz[a,h]anthracene and their 5,6-epoxy-5,6-dihydro derivatives by rat-liver homogenates.

Authors:  E Boyland; P Sims
Journal:  Biochem J       Date:  1965-10       Impact factor: 3.857

7.  In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons.

Authors:  P L Grover; P Sims; E Huberman; H Marquardt; T Kuroki; C Heidelberger
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

8.  The carcinogenicity of polycyclic hydrocarbon epoxides in newborn mice.

Authors:  P L Grover; P Sims; B C Mitchley; F J Roe
Journal:  Br J Cancer       Date:  1975-02       Impact factor: 7.640

9.  TESTS FOR CARCINOGENESIS USING NEWBORN MICE: 1,2BENZANTHRACENE, 2-NAPHTHYLAMINE, 2-NAPHTHYLHYDROXYLAMINE AND ETHYL METHANE SULPHONATE.

Authors:  F J ROE; B C MITCHLEY; M WALTERS
Journal:  Br J Cancer       Date:  1963-06       Impact factor: 7.640

10.  Further studies on incomplete carcinogenesis: triethylene melamine (T.E.M.), 1,2-benzanthracene and beta-propiolactone, as initiators of skin tumour formation in the mouse.

Authors:  F J ROE; M H SALAMAN
Journal:  Br J Cancer       Date:  1955-03       Impact factor: 7.640
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.