OBJECTIVES: To estimate prevalence and incidence of distal symmetric neuropathies (DSN) in the Italian elderly, and to evaluate the accuracy of our procedure to screen for DSN. METHODS: In eight Italian municipalities, a population-based sample was directly evaluated both at baseline (1992) and after a 3-year follow-up. Cohort members who had died were studied. DSN diagnosis and subtyping were made according to specified diagnostic criteria. RESULTS: Our screening procedure proved accurate (sensitivity 94.7%, specificity 70%, positive predictive value 18.9%), and provided an adjusted prevalence of 7.0 (95% CI, 6.9 to 7.0). Women outnumber men both in the oldest age groups and as a whole. Rates increase with increasing age in both genders. Among the 2,845 individuals re-screened at the follow-up and the 221 deceased subjects with reliable information, we identified 100 incident cases of DSN. Adjusted annual incidence rate (per 1,000 person-years) in the population 65 to 84 years of age is 7.9 (95% CI, 6.3 to 9.5), and for the nondiabetic DSN is 5.76 (95% CI, 4.3 to 7.3). Age significantly predicted the onset of DSN both in diabetic individuals (for every increasing year of age RR = 1.07; 95% CI, 1.01 to 1.14) and in the entire study population (RR = 1.05; 95% CI, 1.02 to 1.09). CONCLUSIONS: We provide the first population-based distal symmetric neuropathies incidence data, as well as prevalence rates from an unselected sample of Italian elderly. Distal symmetric neuropathies are an age-associated condition, but the frequency of diabetic distal symmetric neuropathies declines with age, coincident with an increase in nondiabetic cases.
OBJECTIVES: To estimate prevalence and incidence of distal symmetric neuropathies (DSN) in the Italian elderly, and to evaluate the accuracy of our procedure to screen for DSN. METHODS: In eight Italian municipalities, a population-based sample was directly evaluated both at baseline (1992) and after a 3-year follow-up. Cohort members who had died were studied. DSN diagnosis and subtyping were made according to specified diagnostic criteria. RESULTS: Our screening procedure proved accurate (sensitivity 94.7%, specificity 70%, positive predictive value 18.9%), and provided an adjusted prevalence of 7.0 (95% CI, 6.9 to 7.0). Women outnumber men both in the oldest age groups and as a whole. Rates increase with increasing age in both genders. Among the 2,845 individuals re-screened at the follow-up and the 221 deceased subjects with reliable information, we identified 100 incident cases of DSN. Adjusted annual incidence rate (per 1,000 person-years) in the population 65 to 84 years of age is 7.9 (95% CI, 6.3 to 9.5), and for the nondiabetic DSN is 5.76 (95% CI, 4.3 to 7.3). Age significantly predicted the onset of DSN both in diabetic individuals (for every increasing year of age RR = 1.07; 95% CI, 1.01 to 1.14) and in the entire study population (RR = 1.05; 95% CI, 1.02 to 1.09). CONCLUSIONS: We provide the first population-based distal symmetric neuropathies incidence data, as well as prevalence rates from an unselected sample of Italian elderly. Distal symmetric neuropathies are an age-associated condition, but the frequency of diabetic distal symmetric neuropathies declines with age, coincident with an increase in nondiabetic cases.
Authors: Shana M Katzman; Elsa S Strotmeyer; Michael A Nalls; Yiqiang Zhao; Sean Mooney; Nik Schork; Anne B Newman; Tamara B Harris; Kristine Yaffe; Steven R Cummings; Yongmei Liu; Gregory J Tranah Journal: J Gerontol A Biol Sci Med Sci Date: 2014-11-13 Impact factor: 6.053
Authors: Muideen T Olaiya; Robert L Hanson; Karen G Kavena; Madhumita Sinha; Dawn Clary; Mark B Horton; Robert G Nelson; William C Knowler Journal: Diabetes Res Clin Pract Date: 2019-03-25 Impact factor: 5.602
Authors: Kira Leishear; Stephanie A Studenski; Luigi Ferrucci; Nathalie de Rekeneire; Stephen B Kritchevsky; Aaron I Vinik; Eva Hogervorst; Tamara B Harris; Anne B Newman; Elsa S Strotmeyer Journal: J Am Geriatr Soc Date: 2013-02 Impact factor: 5.562
Authors: Rachel E Ward; Paolo Caserotti; Jane A Cauley; Robert M Boudreau; Bret H Goodpaster; Aaron I Vinik; Anne B Newman; Elsa S Strotmeyer Journal: Aging Dis Date: 2015-11-27 Impact factor: 6.745
Authors: Rachel E Ward; Paolo Caserotti; Kimberly Faulkner; Robert M Boudreau; Sasa Zivkovic; Christine Lee; Bret H Goodpaster; Peggy M Cawthon; Anne B Newman; Jane A Cauley; Elsa S Strotmeyer Journal: Arch Phys Med Rehabil Date: 2013-12-16 Impact factor: 3.966
Authors: Rachel E Ward; Robert M Boudreau; Aaron I Vinik; Sasa A Zivkovic; Omer T Njajou; Suzanne Satterfield; Tamara B Harris; Anne B Newman; Elsa S Strotmeyer Journal: Clin Neurophysiol Date: 2012-09-26 Impact factor: 3.708
Authors: Rachel E Ward; Robert M Boudreau; Paolo Caserotti; Tamara B Harris; Sasa Zivkovic; Bret H Goodpaster; Suzanne Satterfield; Stephen B Kritchevsky; Ann V Schwartz; Aaron I Vinik; Jane A Cauley; Eleanor M Simonsick; Anne B Newman; Elsa S Strotmeyer Journal: J Am Geriatr Soc Date: 2014-12-08 Impact factor: 5.562
Authors: Nora A Visser; Nicolette C Notermans; Ferdinand Teding van Berkhout; Leonard H van den Berg; Alexander Fje Vrancken Journal: Chron Respir Dis Date: 2016-03-15 Impact factor: 2.444