Literature DB >> 17470391

Rational design of inhibitors of VirA-VirG two-component signal transduction.

Justin Maresh1, Jin Zhang, Yih-Ling Tzeng, Nora A Goodman, David G Lynn.   

Abstract

VirA-VirG two-component system regulates the vir (virulence) operon in response to specific host factors (xenognosins) in the plant pathogen Agrobacterium tumefaciens. Using whole cell assays, stable inhibitors inspired by the labile natural benzoxazinone inhibitor HDMBOA are developed. It is found that aromatic aldehydes represent a minimal structural unit for activity. In particular, 3-hydroxy-4,6-dimethoxy-3H-isobenzofuran-1-one (HDI) was found to have the highest activity, making it the most potent developed inhibitor of virulence gene expression in Agrobacterium.

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Year:  2007        PMID： 17470391      PMCID： PMC2806187          DOI： 10.1016/j.bmcl.2007.04.018

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Recent advances in the transformation of plants.

Authors: 
Journal:  Trends Plant Sci       Date:  1999-06       Impact factor: 18.313

Review 2.  Inhibitors of bacterial two-component signalling systems.

Authors:  M J Macielag; R Goldschmidt
Journal:  Expert Opin Investig Drugs       Date:  2000-10       Impact factor: 6.206

Review 3.  Chemical biology of multi-host/pathogen interactions: chemical perception and metabolic complementation.

Authors:  Andrew G Palmer; Rong Gao; Justin Maresh; W Kaya Erbil; David G Lynn
Journal:  Annu Rev Phytopathol       Date:  2004       Impact factor: 13.078

4.  PLANT TRANSFORMATION: Problems and Strategies for Practical Application.

Authors:  R. G. Birch
Journal:  Annu Rev Plant Physiol Plant Mol Biol       Date:  1997-06

5.  At the maize/Agrobacterium interface: natural factors limiting host transformation.

Authors:  J Zhang; L Boone; R Kocz; C Zhang; A N Binns; D G Lynn
Journal:  Chem Biol       Date:  2000-08

Review 6.  Chemistry of biologically active benzoxazinoids.

Authors:  Y Hashimoto; K Shudo
Journal:  Phytochemistry       Date:  1996-10       Impact factor: 4.072

7.  The innate immunity of maize and the dynamic chemical strategies regulating two-component signal transduction in Agrobacterium tumefaciens.

Authors:  Justin Maresh; Jin Zhang; David G Lynn
Journal:  ACS Chem Biol       Date:  2006-04-25       Impact factor: 5.100

8.  Mechanism of phenolic activation of Agrobacterium virulence genes: development of a specific inhibitor of bacterial sensor/response systems.

Authors:  K M Hess; M W Dudley; D G Lynn; R D Joerger; A N Binns
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

9.  2-hydroxy-4,7-dimethoxy-1,4-benzoxazin-3-one (N-O-Me-DIMBOA), a possible toxic factor in corn to the southwestern corn borer.

Authors:  P A Hedin; F M Davis; W P Williams
Journal:  J Chem Ecol       Date:  1993-03       Impact factor: 2.626

10.  The genetic and transcriptional organization of the vir region of the A6 Ti plasmid of Agrobacterium tumefaciens.

Authors:  S E Stachel; E W Nester
Journal:  EMBO J       Date:  1986-07       Impact factor: 11.598
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  2 in total

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Authors:  Ming-Che Liu; Shwu-Bin Lin; Hsiung-Fei Chien; Won-Bo Wang; Yu-Han Yuan; Po-Ren Hsueh; Shwu-Jen Liaw
Journal:  PLoS One       Date:  2012-09-20       Impact factor: 3.240

2.  Molecular modeling studies and in vitro screening of dihydrorugosaflavonoid and its derivatives against Mycobacterium tuberculosis.

Authors:  Ninad V Puranik; Pratibha Srivastava; Sagar Swami; Amit Choudhari; Dhiman Sarkar
Journal:  RSC Adv       Date:  2018-03-16       Impact factor: 3.361
  2 in total

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