INTRODUCTION: Alcohol intake has been consistently associated with breast cancer risk, but the importance of timing of intake and the impact of beverage type are unclear. METHODS: We evaluated whether early, lifetime or recent alcohol intake was associated with breast cancer risk, and whether risk varied by type of alcoholic drinks in 1,728 newly diagnosed population-based breast cancer patients and 435 control subjects aged 20-49 years. We used multivariable logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CI) as measures of the relative risk of breast cancer associated with intake of alcoholic drinks. RESULTS: Intake of alcoholic drinks during the recent five year period before the breast cancer diagnosis was associated with increased breast cancer risk (P (trend) = 0.04). Intake of two or more alcoholic drinks per day during this five year period was associated with an 82% increase in breast cancer risk relative to never drinkers (OR = 1.82, 95% CI = 1.01-3.28). No risk increase was observed for alcohol intake at ages 15-20 years or for lifetime alcohol intake. Risk did not vary by type of alcohol consumed. CONCLUSIONS: Our results suggest that recent alcohol consumption may be associated with increased breast cancer risk in young women.
INTRODUCTION:Alcohol intake has been consistently associated with breast cancer risk, but the importance of timing of intake and the impact of beverage type are unclear. METHODS: We evaluated whether early, lifetime or recent alcohol intake was associated with breast cancer risk, and whether risk varied by type of alcoholic drinks in 1,728 newly diagnosed population-based breast cancerpatients and 435 control subjects aged 20-49 years. We used multivariable logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CI) as measures of the relative risk of breast cancer associated with intake of alcoholic drinks. RESULTS: Intake of alcoholic drinks during the recent five year period before the breast cancer diagnosis was associated with increased breast cancer risk (P (trend) = 0.04). Intake of two or more alcoholic drinks per day during this five year period was associated with an 82% increase in breast cancer risk relative to never drinkers (OR = 1.82, 95% CI = 1.01-3.28). No risk increase was observed for alcohol intake at ages 15-20 years or for lifetime alcohol intake. Risk did not vary by type of alcohol consumed. CONCLUSIONS: Our results suggest that recent alcohol consumption may be associated with increased breast cancer risk in young women.
Authors: Catherine S Berkey; Walter C Willett; A Lindsay Frazier; Bernard Rosner; Rulla M Tamimi; Helaine R H Rockett; Graham A Colditz Journal: Pediatrics Date: 2010-04-12 Impact factor: 7.124
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Authors: Lívia Emi Inumaru; Maíra Irineu Gomes Duarte Quintanilha; Érika Aparecida da Silveira; Maria Margareth Veloso Naves Journal: J Environ Public Health Date: 2012-05-15