Literature DB >> 17468659

Serum antibodies to the pneumococcal surface proteins PhtB and PhtE in Finnish infants and adults.

Emma Holmlund1, Birgit Simell, Teija Jaakkola, Mika Lahdenkari, Josée Hamel, Bernard Brodeur, Terhi Kilpi, Helena Käyhty.   

Abstract

We examined naturally acquired antibodies to pneumococcal vaccine candidate proteins PhtB and PhtE in children during their first 2 years of life. Prior culture-confirmed pneumococcal exposure was shown to induce the development of anti-PhtB and -PhtE antibodies. The anti-PhtB or -PhtE antibody concentrations were not significantly associated with a decreased risk of subsequent pneumococcal acute otitis media.

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Year:  2007        PMID： 17468659     DOI： 10.1097/01.inf.0000261198.90649.04

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   2.129


  8 in total

1.  Natural antibodies against several pneumococcal virulence proteins in children during the pre-pneumococcal-vaccine era: the generation R study.

Authors:  Ankie Lebon; Nelianne J Verkaik; Joost A M Labout; Corné P de Vogel; Herbert Hooijkaas; Henri A Verbrugh; Willem J B van Wamel; Vincent W V Jaddoe; Albert Hofman; Peter W M Hermans; Jiangtao Ma; Tim J Mitchell; Henriette A Moll; Alex van Belkum
Journal:  Infect Immun       Date:  2011-01-31       Impact factor: 3.441

2.  Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children.

Authors:  Ravinder Kaur; Janet R Casey; Michael E Pichichero
Journal:  Pediatr Infect Dis J       Date:  2011-08       Impact factor: 2.129

3.  Interaction of pneumococcal histidine triad proteins with human complement.

Authors:  Merit Melin; Emmanuel Di Paolo; Leena Tikkanen; Hanna Jarva; Cecile Neyt; Helena Käyhty; Seppo Meri; Jan Poolman; Merja Väkeväinen
Journal:  Infect Immun       Date:  2010-03-01       Impact factor: 3.441

4.  Preclinical evaluation of the Pht proteins as potential cross-protective pneumococcal vaccine antigens.

Authors:  Fabrice Godfroid; Philippe Hermand; Vincent Verlant; Philippe Denoël; Jan T Poolman
Journal:  Infect Immun       Date:  2010-10-18       Impact factor: 3.441

5.  Influence of age, social patterns and nasopharyngeal carriage on antibodies to three conserved pneumococcal surface proteins (PhtD, PcpA and PrtA) in healthy young children.

Authors:  A Hagerman; K M Posfay-Barbe; S Grillet; M M Ochs; R H Brookes; D Greenberg; N Givon-Lavi; R Dagan; C-A Siegrist
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2012-08-18       Impact factor: 3.267

6.  Antibodies to pneumococcal proteins PhtD, CbpA, and LytC in Filipino pregnant women and their infants in relation to pneumococcal carriage.

Authors:  Emma Holmlund; Beatriz Quiambao; Jukka Ollgren; Teija Jaakkola; Cécile Neyt; Jan Poolman; Hanna Nohynek; Helena Käyhty
Journal:  Clin Vaccine Immunol       Date:  2009-04-29

7.  Development of antibodies to PspA families 1 and 2 in children after exposure to Streptococcus pneumoniae.

Authors:  Merit M Melin; Susan K Hollingshead; David E Briles; Mika I Lahdenkari; Terhi M Kilpi; Helena M Käyhty
Journal:  Clin Vaccine Immunol       Date:  2008-08-27

8.  Australian Aboriginal Children with Otitis Media Have Reduced Antibody Titers to Specific Nontypeable Haemophilus influenzae Vaccine Antigens.

Authors:  Ruth B Thornton; Lea-Ann S Kirkham; Karli J Corscadden; Selma P Wiertsema; Angela Fuery; B Jan Jones; Harvey L Coates; Shyan Vijayasekaran; Guicheng Zhang; Anthony Keil; Peter C Richmond
Journal:  Clin Vaccine Immunol       Date:  2017-04-05
  8 in total

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