Literature DB >> 17468444

Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis.

Y Zhang1, R K Zabad, X Wei, L M Metz, M D Hill, J R Mitchell.   

Abstract

T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5 T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3 T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.

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Year:  2007        PMID: 17468444     DOI: 10.1177/1352458507076411

Source DB:  PubMed          Journal:  Mult Scler        ISSN: 1352-4585            Impact factor:   6.312


  13 in total

Review 1.  Pathogenic implications of iron accumulation in multiple sclerosis.

Authors:  Rachel Williams; Cassandra L Buchheit; Nancy E J Berman; Steven M LeVine
Journal:  J Neurochem       Date:  2011-11-11       Impact factor: 5.372

Review 2.  MRI in multiple sclerosis: what's inside the toolbox?

Authors:  Mohit Neema; James Stankiewicz; Ashish Arora; Zachary D Guss; Rohit Bakshi
Journal:  Neurotherapeutics       Date:  2007-10       Impact factor: 7.620

Review 3.  MRI in multiple sclerosis: current status and future prospects.

Authors:  Rohit Bakshi; Alan J Thompson; Maria A Rocca; Daniel Pelletier; Vincent Dousset; Frederik Barkhof; Matilde Inglese; Charles R G Guttmann; Mark A Horsfield; Massimo Filippi
Journal:  Lancet Neurol       Date:  2008-07       Impact factor: 44.182

4.  Post-acute pathological changes in the thalamus and internal capsule in aged mice following controlled cortical impact injury: a magnetic resonance imaging, iron histochemical, and glial immunohistochemical study.

Authors:  Gregory Onyszchuk; Steven M LeVine; William M Brooks; Nancy E J Berman
Journal:  Neurosci Lett       Date:  2009-01-23       Impact factor: 3.046

5.  Caudate nuclei volume, diffusion tensor metrics, and T(2) relaxation in healthy adults and relapsing-remitting multiple sclerosis patients: implications for understanding gray matter degeneration.

Authors:  Khader M Hasan; Christopher Halphen; Arash Kamali; Flavia M Nelson; Jerry S Wolinsky; Ponnada A Narayana
Journal:  J Magn Reson Imaging       Date:  2009-01       Impact factor: 4.813

Review 6.  Visualizing iron in multiple sclerosis.

Authors:  Francesca Bagnato; Simon Hametner; Edward Brian Welch
Journal:  Magn Reson Imaging       Date:  2013-01-22       Impact factor: 2.546

Review 7.  Iron in chronic brain disorders: imaging and neurotherapeutic implications.

Authors:  James Stankiewicz; S Scott Panter; Mohit Neema; Ashish Arora; Courtney E Batt; Rohit Bakshi
Journal:  Neurotherapeutics       Date:  2007-07       Impact factor: 7.620

8.  Sample size requirements for treatment effects using gray matter, white matter and whole brain volume in relapsing-remitting multiple sclerosis.

Authors:  B Healy; P Valsasina; M Filippi; R Bakshi
Journal:  J Neurol Neurosurg Psychiatry       Date:  2009-02-09       Impact factor: 10.154

9.  Deep gray matter T2 hypointensity correlates with disability in a murine model of MS.

Authors:  Istvan Pirko; Aaron J Johnson; Anne K Lohrey; Yi Chen; Jun Ying
Journal:  J Neurol Sci       Date:  2009-01-21       Impact factor: 3.181

10.  Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis.

Authors:  Mohit Neema; Ashish Arora; Brian C Healy; Zachary D Guss; Steven D Brass; Yang Duan; Guy J Buckle; Bonnie I Glanz; Lynn Stazzone; Samia J Khoury; Howard L Weiner; Charles R G Guttmann; Rohit Bakshi
Journal:  J Neuroimaging       Date:  2009-01       Impact factor: 2.486

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