| Literature DB >> 17468055 |
Farnaz Esmaeili1, Mahdi Hosseini-Nasr, Mazda Rad-Malekshahi, Nasrin Samadi, Fatemeh Atyabi, Rassoul Dinarvand.
Abstract
Biodegradable polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). In this study, rifampicin (RIF)-loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method. The effect of several variables on the NPs' characteristics were evaluated, including the amount of RIF, amount of the poly vinyl alcohol as surfactant, and internal-phase volume and composition. The RIF encapsulation efficacy and the particle size distribution were optimized by varying these parameters. NPs were spherical with a relatively monodispersed size distribution. The effect of nanoencapsulation of RIF on the antibacterial activity of RIF against gram-positive and gram-negative bacteria was evaluated. It was shown that RIF NPs could considerably improve the RIF antibacterial efficacy.Entities:
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Year: 2007 PMID： 17468055 DOI： 10.1016/j.nano.2007.03.003
Source DB: PubMed Journal: Nanomedicine ISSN： 1549-9634 Impact factor: 5.307