Literature DB >> 17467984

Oxadiazole mannich bases: synthesis and antimycobacterial activity.

Mohamed Ashraf Ali1, Mohammad Shaharyar.   

Abstract

A series of oxadiazole mannich bases were synthesized by reacting oxadiazole derivatives, dapsone and appropriate aldehyde in the presence of methanol. The synthesized compounds were evaluated for antimycobacterial activity against M. tuberculosis H(37)Rv and INH resistant M. tuberculosis. Among the synthesized compounds, compound (4) 3-{2-furyl[4-(4-{2-furyl[5-(2-naphthyloxymethyl)-2-thioxo-2,3-dihydro-1,3,4-oxadiazol-3-yl]methylamino}phenylsulfonyl)anilino]methyl}-5-(2-naphthyloxymethyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione was found to be the most promising compound active against M. tuberculosis H(37)Rv and isoniazid (INH) resistant M. tuberculosis with Minimum inhibitory concentration (MIC) 0.1 microM & 1.10 microM respectively.

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Year:  2007        PMID： 17467984     DOI： 10.1016/j.bmcl.2007.04.004

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Synthesis and Biological Evaluation of beta-Aroylpropionic acid based 1,3,4-Oxadiazoles.

Authors:  A Husain; Priyanka Ahuja
Journal:  Indian J Pharm Sci       Date:  2009-01       Impact factor: 0.975

Review 2.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

Review 3.  Mannich bases: an important pharmacophore in present scenario.

Authors:  Suman Bala; Neha Sharma; Anu Kajal; Sunil Kamboj; Vipin Saini
Journal:  Int J Med Chem       Date:  2014-11-12

4.  Novel biphenyl-substituted 1,2,4-oxadiazole ferroelectric liquid crystals: synthesis and characterization.

Authors:  Mahabaleshwara Subrao; Dakshina Murthy Potukuchi; Girish Sharada Ramachandra; Poornima Bhagavath; Sangeetha G Bhat; Srinivasulu Maddasani
Journal:  Beilstein J Org Chem       Date:  2015-02-11       Impact factor: 2.883

5.  Synthesis, antiproliferative activity and molecular properties predictions of galloyl derivatives.

Authors:  Marciane Maximo da Silva; Marina Comin; Thiago Santos Duarte; Mary Ann Foglio; João Ernesto de Carvalho; Maria Carmo do Vieira; Anelise Samara Nazari Formagio
Journal:  Molecules       Date:  2015-03-25       Impact factor: 4.411

6.  Synthesis and Screening of New [1,3,4]Oxadiazole, [1,2,4]Triazole, and [1,2,4]Triazolo[4,3-b][1,2,4]triazole Derivatives as Potential Antitumor Agents on the Colon Carcinoma Cell Line (HCT-116).

Authors:  El-Sayed M Abdelrehim
Journal:  ACS Omega       Date:  2021-01-07

Review 7.  Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives.

Authors:  Teresa Glomb; Piotr Świątek
Journal:  Int J Mol Sci       Date:  2021-06-29       Impact factor: 5.923

8.  Synthesis, characterization, and in vitro anticancer evaluation of novel 2,5-disubstituted 1,3,4-oxadiazole analogue.

Authors:  Avijit Mazumder; Mohammad Shaharyar
Journal:  Biomed Res Int       Date:  2014-08-10       Impact factor: 3.411

Review 9.  Synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles: a review of the literature from 2000-2012.

Authors:  Cledualdo Soares de Oliveira; Bruno Freitas Lira; José Maria Barbosa-Filho; Jorge Gonçalo Fernandez Lorenzo; Petrônio Filgueiras de Athayde-Filho
Journal:  Molecules       Date:  2012-08-27       Impact factor: 4.411
  9 in total

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