OBJECTIVE: This study aimed to examine the expression patterns of pro- and anti-inflammatory cytokines in elderly patients with and without delirium who were acutely admitted to the hospital. METHODS: All consecutive patients aged 65 years and older, who were acutely admitted to the Department of Internal Medicine of the Academic Medical Center, Amsterdam, a tertiary university teaching hospital, were invited. Members of the geriatric consultation team completed a multidisciplinary evaluation for all study participants within 48 h after admission, including cognitive and functional examination by validated measures of delirium, memory, and executive function. C-reactive protein and cytokines (IL-1beta, IL-6, TNF-alpha, IL-8, and IL-10) were determined within 3 days after admission. RESULTS: In total, 185 patients were included; mean age was 79 years; 42% were male; and 34.6% developed delirium within 48 h after admission. Compared to patients without delirium, patients with delirium were older and had experienced preexistent cognitive impairment more often. In patients with delirium, significantly more IL-6 levels (53% vs. 31%) and IL-8 levels (45% vs. 22%) were above the detection limit as compared with patients who did not have delirium. After adjusting for infection, age, and cognitive impairment, these differences were still significant. CONCLUSIONS: Proinflammatory cytokines may contribute to the pathogenesis of delirium in acutely admitted elderly patients.
OBJECTIVE: This study aimed to examine the expression patterns of pro- and anti-inflammatory cytokines in elderly patients with and without delirium who were acutely admitted to the hospital. METHODS: All consecutive patients aged 65 years and older, who were acutely admitted to the Department of Internal Medicine of the Academic Medical Center, Amsterdam, a tertiary university teaching hospital, were invited. Members of the geriatric consultation team completed a multidisciplinary evaluation for all study participants within 48 h after admission, including cognitive and functional examination by validated measures of delirium, memory, and executive function. C-reactive protein and cytokines (IL-1beta, IL-6, TNF-alpha, IL-8, and IL-10) were determined within 3 days after admission. RESULTS: In total, 185 patients were included; mean age was 79 years; 42% were male; and 34.6% developed delirium within 48 h after admission. Compared to patients without delirium, patients with delirium were older and had experienced preexistent cognitive impairment more often. In patients with delirium, significantly more IL-6 levels (53% vs. 31%) and IL-8 levels (45% vs. 22%) were above the detection limit as compared with patients who did not have delirium. After adjusting for infection, age, and cognitive impairment, these differences were still significant. CONCLUSIONS: Proinflammatory cytokines may contribute to the pathogenesis of delirium in acutely admitted elderly patients.
Authors: Konstanze Plaschke; Philipp Fichtenkamm; Christoph Schramm; Steffen Hauth; Eike Martin; Markus Verch; Matthias Karck; Jürgen Kopitz Journal: Intensive Care Med Date: 2010-08-06 Impact factor: 17.440
Authors: Sarinnapha M Vasunilashorn; Long Ngo; Sharon K Inouye; Towia A Libermann; Richard N Jones; David C Alsop; Jamey Guess; Sandra Jastrzebski; Janet E McElhaney; George A Kuchel; Edward R Marcantonio Journal: J Gerontol A Biol Sci Med Sci Date: 2015-07-27 Impact factor: 6.053
Authors: Phillip E Vlisides; Aleda Thompson; Bryan S Kunkler; Hannah R Maybrier; Michael S Avidan; George A Mashour Journal: Anesth Analg Date: 2019-05 Impact factor: 5.108
Authors: Chani Traube; Gabrielle Silver; Ron W Reeder; Hannah Doyle; Emily Hegel; Heather A Wolfe; Christopher Schneller; Melissa G Chung; Leslie A Dervan; Jane L DiGennaro; Sandra D W Buttram; Sapna R Kudchadkar; Kate Madden; Mary E Hartman; Mary L deAlmeida; Karen Walson; Erwin Ista; Manuel A Baarslag; Rosanne Salonia; John Beca; Debbie Long; Yu Kawai; Ira M Cheifetz; Javier Gelvez; Edward J Truemper; Rebecca L Smith; Megan E Peters; A M Iqbal O'Meara; Sarah Murphy; Abdulmohsen Bokhary; Bruce M Greenwald; Michael J Bell Journal: Crit Care Med Date: 2017-04 Impact factor: 7.598
Authors: Subash C Gupta; Ji Hye Kim; Ramaswamy Kannappan; Simone Reuter; Patrick M Dougherty; Bharat B Aggarwal Journal: Exp Biol Med (Maywood) Date: 2011-05-12
Authors: Timothy D Girard; Lorraine B Ware; Gordon R Bernard; Pratik P Pandharipande; Jennifer L Thompson; Ayumi K Shintani; James C Jackson; Robert S Dittus; E Wesley Ely Journal: Intensive Care Med Date: 2012-08-18 Impact factor: 17.440
Authors: Pratik P Pandharipande; Robert D Sanders; Timothy D Girard; Stuart McGrane; Jennifer L Thompson; Ayumi K Shintani; Daniel L Herr; Mervyn Maze; E Wesley Ely Journal: Crit Care Date: 2010-03-16 Impact factor: 9.097