OBJECTIVE: We hypothesized that undernutrition in utero alters the structure of conduit and resistance vessels early in development. STUDY DESIGN: We studied a rodent model in which dams were 50% food restricted from day 10 of gestation to term. Vascular smooth muscle content and vascular caliber in the offspring were examined by quantitative histologic methods and by Western blot analysis. RESULTS: Maternal food restriction induced a significant increase in the smooth muscle content of 1-day- and 2-month-old offspring aortas and mesenteric arterioles of different luminal diameters. Histologic data were confirmed by Western blot analysis that showed greater expression of smooth muscle alpha-actin in 1-day-old food restriction aortas. The increase in vascular smooth muscle in the aortas was determined to be the result of cellular hypertrophy. CONCLUSION: These results demonstrate that the vascular smooth muscle is altered in food-restriction offspring and that this may be a mechanism for the programming of offspring hypertension.
OBJECTIVE: We hypothesized that undernutrition in utero alters the structure of conduit and resistance vessels early in development. STUDY DESIGN: We studied a rodent model in which dams were 50% food restricted from day 10 of gestation to term. Vascular smooth muscle content and vascular caliber in the offspring were examined by quantitative histologic methods and by Western blot analysis. RESULTS: Maternal food restriction induced a significant increase in the smooth muscle content of 1-day- and 2-month-old offspring aortas and mesenteric arterioles of different luminal diameters. Histologic data were confirmed by Western blot analysis that showed greater expression of smooth muscle alpha-actin in 1-day-old food restriction aortas. The increase in vascular smooth muscle in the aortas was determined to be the result of cellular hypertrophy. CONCLUSION: These results demonstrate that the vascular smooth muscle is altered in food-restriction offspring and that this may be a mechanism for the programming of offspring hypertension.
Authors: O Khorram; G Han; R Bagherpour; T R Magee; M Desai; M G Ross; A A Chaudhri; T Toloubeydokhti; W J Pearce Journal: Am J Physiol Regul Integr Comp Physiol Date: 2010-03-03 Impact factor: 3.619
Authors: Lara M Durrant; Omid Khorram; John N Buchholz; William J Pearce Journal: Am J Physiol Regul Integr Comp Physiol Date: 2014-01-29 Impact factor: 3.619
Authors: Tiago J Costa; Júlio Cezar De Oliveira; Fernanda Regina Giachini; Victor Vitorino Lima; Rita C Tostes; Gisele Facholi Bomfim Journal: Front Physiol Date: 2022-03-10 Impact factor: 4.566