| Literature DB >> 17466597 |
Andrea L Graham1, Isabella M Cattadori, James O Lloyd-Smith, Matthew J Ferrari, Ottar N Bjørnstad.
Abstract
Coinfection of a host by multiple parasite species is commonly observed and recent epidemiological work indicates that coinfection can enhance parasite transmission. This article proposes an immunoepidemiological framework to understand how within-host interactions during coinfection might affect between-host transmission. Cytokines, immune signalling molecules with a fundamental role in the amplification of antiparasitic effector mechanisms, provide a useful way to simplify immunological complexity for this endeavour--focusing on cytokines offers analytical tractability without sacrificing realism. Testable predictions about the epidemiological consequences of coinfection are generated by this conceptual framework.Mesh：
Substances：
Year: 2007 PMID： 17466597 DOI： 10.1016/j.pt.2007.04.005
Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922