| Literature DB >> 17466519 |
Brian J Lavey1, Joseph A Kozlowski, Bandarpalle B Shankar, James M Spitler, Guowei Zhou, De-Yi Yang, Youheng Shu, Michael K C Wong, Shing-Chun Wong, Neng-Yang Shih, Jie Wu, Stuart W McCombie, Razia Rizvi, Ronald L Wolin, Charles A Lunn.
Abstract
Structure-activity relationship on our recently reported triaryl bis-sulfone class of cannabinoid-2 (CB2) receptor selective inverse agonists was explored. Modifications to the methane sulfonamide, substitutions to B and C phenyl rings, and replacements of the C-ring were investigated. A compound with excellent CB2 activity, selectivity for CB2 over CB1, and in vivo plasma levels was identified.Entities:
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Year: 2007 PMID： 17466519 DOI： 10.1016/j.bmcl.2007.04.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823