Literature DB >> 17465727

The potential for phospholipase D as a new therapeutic target.

Ping Huang1, Michael A Frohman.   

Abstract

Mammalian phospholipase D (PLD), a signal transduction-activated enzyme, hydrolyzes phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. Genetic and pharmacological methods have implicated PLD and its product PA in a wide variety of cellular processes including vesicle trafficking, receptor signaling, cell proliferation and survival. Dysregulation of these cell biologic processes occurs in a diverse range of illnesses including cancer. This review summarizes PLD regulation and function and highlights its potential as a therapeutic target in disease settings.

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Year:  2007        PMID： 17465727     DOI： 10.1517/14728222.11.5.707

Source DB:  PubMed          Journal:  Expert Opin Ther Targets        ISSN： 1472-8222            Impact factor:   6.902


  37 in total

Review 1.  Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis.

Authors:  Qun Gao; Michael A Frohman
Journal:  BMB Rep       Date:  2012-01       Impact factor: 4.778

Review 2.  Choline and betaine in health and disease.

Authors:  Per Magne Ueland
Journal:  J Inherit Metab Dis       Date:  2010-05-06       Impact factor: 4.982

3.  Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes.

Authors:  Chunfa Huang; Leslie A Bruggeman; Lindsey M Hydo; R Tyler Miller
Journal:  Exp Cell Res       Date:  2012-03-26       Impact factor: 3.905

4.  Effect of mixed-phospholipid layer on phospholipase D reaction-induced vesicle rupture.

Authors:  Jin-Won Park
Journal:  J Membr Biol       Date:  2012-05-25       Impact factor: 1.843

5.  Phospholipase D epsilon and phosphatidic acid enhance Arabidopsis nitrogen signaling and growth.

Authors:  Yueyun Hong; Shivakumar P Devaiah; Sung Chul Bahn; Bharath N Thamasandra; Maoyin Li; Ruth Welti; Xuemin Wang
Journal:  Plant J       Date:  2009-01-08       Impact factor: 6.417

Review 6.  Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis.

Authors:  Wenjuan Su; Qin Chen; Michael A Frohman
Journal:  Future Oncol       Date:  2009-11       Impact factor: 3.404

7.  Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages.

Authors:  Laura Fantuzzi; Francesca Spadaro; Cristina Purificato; Serena Cecchetti; Franca Podo; Filippo Belardelli; Sandra Gessani; Carlo Ramoni
Journal:  Blood       Date:  2008-01-18       Impact factor: 22.113

8.  Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.

Authors:  Margitta Elvers; David Stegner; Ina Hagedorn; Christoph Kleinschnitz; Attila Braun; Marijke E J Kuijpers; Michael Boesl; Qin Chen; Johan W M Heemskerk; Guido Stoll; Michael A Frohman; Bernhard Nieswandt
Journal:  Sci Signal       Date:  2010-01-05       Impact factor: 8.192

9.  Use of gene expression profiles in cells of peripheral blood to identify new molecular markers of acute pancreatitis.

Authors:  Martin Bluth; Yin-Yao Lin; Hong Zhang; Domenico Viterbo; Michael Zenilman
Journal:  Arch Surg       Date:  2008-03

10.  Gramicidin pores report the activity of membrane-active enzymes.

Authors:  Sheereen Majd; Erik C Yusko; Alexander D MacBriar; Jerry Yang; Michael Mayer
Journal:  J Am Chem Soc       Date:  2009-11-11       Impact factor: 15.419
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