AIM: To explore a specific diagnostic method for local recurrent rectal cancer. METHODS: Immunoscintigraphy with (99m)Tc-labeled anti-CEA monoclonal antibody (MoAb) CL-58 was performed for patients suspected of having a postoperative local recurrent rectal cancer and the findings were compared with the results of conventional imaging and pathology. RESULTS: A total of 36 patients with a suspected local recurrent rectal cancer underwent immunoscintigraphy with (99m)Tc-conjugated CL58. Local recurrence of rectal cancer was identified in 31 patients and established in 30 during operation, endoscopy and pathological examination. No local recurrence was found in 5 patients without specific accumulation of (99m)Tc during the follow-up. Immunoscintigraphy had a positive rate of 86.11%, a specificity of 83.33%, and a sensitivity of 100%. CONCLUSION: Immunoscintigraphy has a highly specific and predictive value for detecting local recurrent rectal cancer, especially after abdominal perineal resection (APR).
AIM: To explore a specific diagnostic method for local recurrent rectal cancer. METHODS: Immunoscintigraphy with (99m)Tc-labeled anti-CEA monoclonal antibody (MoAb) CL-58 was performed for patients suspected of having a postoperative local recurrent rectal cancer and the findings were compared with the results of conventional imaging and pathology. RESULTS: A total of 36 patients with a suspected local recurrent rectal cancer underwent immunoscintigraphy with (99m)Tc-conjugated CL58. Local recurrence of rectal cancer was identified in 31 patients and established in 30 during operation, endoscopy and pathological examination. No local recurrence was found in 5 patients without specific accumulation of (99m)Tc during the follow-up. Immunoscintigraphy had a positive rate of 86.11%, a specificity of 83.33%, and a sensitivity of 100%. CONCLUSION: Immunoscintigraphy has a highly specific and predictive value for detecting local recurrent rectal cancer, especially after abdominal perineal resection (APR).
Authors: F Baulieu; P Bourlier; B Scotto; C Mor; V Eder; L Picon; L De Calan; E Dorval; J M Pottier; J L Baulieu Journal: Nucl Med Commun Date: 2001-12 Impact factor: 1.690
Authors: P A Lucha; L Rosen; J A Olenwine; J F Reed; R D Riether; J J Stasik; I T Khubchandani Journal: Dis Colon Rectum Date: 1997-02 Impact factor: 4.585
Authors: Enrique Hernandez de Anda; Suk-Hawn Lee; Charles O Finne; David A Rothenberger; Robert D Madoff; Julio Garcia-Aguilar Journal: Dis Colon Rectum Date: 2004-04-19 Impact factor: 4.585