OBJECTIVE: To explore the relationships between sociodemographic and clinical factors and quality of life (QOL) in a cohort of Chinese schizophrenia outpatients. METHOD: Two hundred subjects with a diagnosis of DSM-IV schizophrenia aged 18-60 years were randomly selected, and their sociodemographic and clinical characteristics including psychotic and depressive symptoms, extrapyramidal symptoms (EPS), and quality of life were assessed. Correlation and multiple regression analyses were used to evaluate the relationships of sociodemographic, clinical data and QOL. RESULTS: Compared to normative data obtained for the general population in Hong Kong, significantly lower scores in physical, psychological, and social QOL domains were found in the patient group. History of suicidal attempts and the presence of positive, negative, depressive, anxiety and EPS symptoms were all significantly correlated with QOL in schizophrenia patients. After controlling for the effects of variables that were significantly correlated with QOL in the correlation analysis, however, only depressive symptoms were still significantly correlated with each QOL domain. Multiple regression analysis showed that depressive symptoms predicted all QOL domains, while positive symptoms predicted overall and physical QOL domains. CONCLUSIONS: Chinese outpatients with schizophrenia had poorer QOL than the general population. In this patient population, QOL was more strongly related to the severity of depressive symptoms and was independent of sociodemographic factors.
OBJECTIVE: To explore the relationships between sociodemographic and clinical factors and quality of life (QOL) in a cohort of Chinese schizophrenia outpatients. METHOD: Two hundred subjects with a diagnosis of DSM-IV schizophrenia aged 18-60 years were randomly selected, and their sociodemographic and clinical characteristics including psychotic and depressive symptoms, extrapyramidal symptoms (EPS), and quality of life were assessed. Correlation and multiple regression analyses were used to evaluate the relationships of sociodemographic, clinical data and QOL. RESULTS: Compared to normative data obtained for the general population in Hong Kong, significantly lower scores in physical, psychological, and social QOL domains were found in the patient group. History of suicidal attempts and the presence of positive, negative, depressive, anxiety and EPS symptoms were all significantly correlated with QOL in schizophreniapatients. After controlling for the effects of variables that were significantly correlated with QOL in the correlation analysis, however, only depressive symptoms were still significantly correlated with each QOL domain. Multiple regression analysis showed that depressive symptoms predicted all QOL domains, while positive symptoms predicted overall and physical QOL domains. CONCLUSIONS: Chinese outpatients with schizophrenia had poorer QOL than the general population. In this patient population, QOL was more strongly related to the severity of depressive symptoms and was independent of sociodemographic factors.
Authors: Yu-Tao Xiang; Chuan-Yue Wang; Ying Wang; Helen F K Chiu; Jing-Ping Zhao; Qi Chen; Sandra S M Chan; Edwin H M Lee; Gabor S Ungvari Journal: Qual Life Res Date: 2010-02-05 Impact factor: 4.147
Authors: Adesanmi Akinsulore; Olutayo O Aloba; B M Mapayi; I O Oloniniyi; F O Fatoye; R O A Makanjuola Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2014-02-19 Impact factor: 4.328
Authors: William Montgomery; Li Liu; Michael D Stensland; Hai Bo Xue; Tamas Treuer; Haya Ascher-Svanum Journal: Clinicoecon Outcomes Res Date: 2013-08-14
Authors: William Montgomery; Tamas Treuer; Wenyu Ye; Hai Bo Xue; Sheng Hu Wu; Li Liu; Zbigniew Kadziola; Michael D Stensland; Haya Ascher-Svanum Journal: Neuropsychiatr Dis Treat Date: 2014-07-10 Impact factor: 2.570