| Literature DB >> 17461892 |
Anita Siu1, Richard Drachtman.
Abstract
Dextromethorphan (DM) is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, which is widely used as an antitussive agent. DM also prevents neuronal damage and modulates pain sensation via noncompetitive antagonism of excitatory amino acids (EAAs). DM has been found to be useful in the treatment of pain in cancer patients and in the treatment of methotrexate-induced neurotoxicity. Clinical studies with DM in cancer patients are reviewed in this article.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17461892 PMCID： PMC6494157 DOI： 10.1111/j.1527-3458.2007.00006.x
Source DB: PubMed Journal: CNS Drug Rev ISSN： 1080-563X