AIM: To determine the timing of mortality after onset of severe acute pancreatitis (SAP) and the course of the disease in a large series of patients. METHODS: From July 1996 to June 2005, all patients diagnosed with acute pancreatitis at Chang Gung Memorial Hospital, Taipei, Taiwan were retrospectively studied. Three thousand two hundred and fifty episodes of acute pancreatitis were recorded in 2248 patients (1431 males and 817 females; median age, 55.6 years; range, 18-97 years). Mortality was divided into two groups: early death (<= 14 d after admission), and late death (> 14 d after admission). The clinical features of patients in these two groups were compared. RESULTS: Although the overall mortality rate of acute pancreatitis was 3.8% (123/3250), mortality rate of SAP was as high as 16.3% (105/643). Of those 105 SAP mortalities, 44 (41.9%) deaths occurred within the first 14 d after admission and 61 (58.1%) occurred after14 d. Incidence of early death did not significantly differ from that of late death. The co-morbidities did not contribute to the timing of death. Early deaths mainly resulted from multiple organ failure. Late deaths were mainly caused by secondary complication of infected necrosis. Intra-abdominal bleeding significantly caused higher mortality in late death. CONCLUSION: Approximately half (42%) of SAP deaths occur within 14 d and most were due to multiple organ failure. The late deaths of SAP were mostly due to infected necrosis.
AIM: To determine the timing of mortality after onset of severe acute pancreatitis (SAP) and the course of the disease in a large series of patients. METHODS: From July 1996 to June 2005, all patients diagnosed with acute pancreatitis at Chang Gung Memorial Hospital, Taipei, Taiwan were retrospectively studied. Three thousand two hundred and fifty episodes of acute pancreatitis were recorded in 2248 patients (1431 males and 817 females; median age, 55.6 years; range, 18-97 years). Mortality was divided into two groups: early death (<= 14 d after admission), and late death (> 14 d after admission). The clinical features of patients in these two groups were compared. RESULTS: Although the overall mortality rate of acute pancreatitis was 3.8% (123/3250), mortality rate of SAP was as high as 16.3% (105/643). Of those 105 SAP mortalities, 44 (41.9%) deaths occurred within the first 14 d after admission and 61 (58.1%) occurred after14 d. Incidence of early death did not significantly differ from that of late death. The co-morbidities did not contribute to the timing of death. Early deaths mainly resulted from multiple organ failure. Late deaths were mainly caused by secondary complication of infected necrosis. Intra-abdominal bleeding significantly caused higher mortality in late death. CONCLUSION: Approximately half (42%) of SAP deaths occur within 14 d and most were due to multiple organ failure. The late deaths of SAP were mostly due to infected necrosis.
Authors: G Talamini; C Bassi; M Falconi; N Sartori; L Frulloni; V Di Francesco; S Vesentini; P Pederzoli; G Cavallini Journal: Int J Pancreatol Date: 1996-02
Authors: P G Lankisch; S Burchard-Reckert; M Petersen; D Lehnick; C A Schirren; H Köhler; F Stöckmann; H J Peiper; W Creutzfeldt Journal: Z Gastroenterol Date: 1996-06 Impact factor: 2.000
Authors: Catherine A Foss; Liansheng Liu; Ronnie C Mease; Haofan Wang; Pankaj Pasricha; Martin G Pomper Journal: J Nucl Med Date: 2017-05-18 Impact factor: 10.057
Authors: Pawan Noel; Krutika Patel; Chandra Durgampudi; Ram N Trivedi; Cristiane de Oliveira; Michael D Crowell; Rahul Pannala; Kenneth Lee; Randall Brand; Jennifer Chennat; Adam Slivka; Georgios I Papachristou; Asif Khalid; David C Whitcomb; James P DeLany; Rachel A Cline; Chathur Acharya; Deepthi Jaligama; Faris M Murad; Dhiraj Yadav; Sarah Navina; Vijay P Singh Journal: Gut Date: 2014-12-10 Impact factor: 23.059
Authors: Krutika Patel; Ram N Trivedi; Chandra Durgampudi; Pawan Noel; Rachel A Cline; James P DeLany; Sarah Navina; Vijay P Singh Journal: Am J Pathol Date: 2015-01-08 Impact factor: 4.307
Authors: M S Kapranov; A D Kiselev; S L Brukh; S S Lugovskoi; K G Maslov; I B Kovalenko; A L Iarosh; E Alkanany Journal: Arch Razi Inst Date: 2022-02-28
Authors: James R A Skipworth; Rian M Nijmeijer; Hjalmar C van Santvoort; Marc G H Besselink; Hans-Ulrich Schulz; Mika Kivimaki; Meena Kumari; Jackie A Cooper; Jay Acharya; Arjun Shankar; Massimo Malago; Steve E Humphries; Steven W M Olde Damink; Hugh E Montgomery Journal: Ann Surg Date: 2015-01 Impact factor: 12.969