Literature DB >> 17460694

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.

Ashley E Sims1, Elizabeth Spiteri, Robert J Sims, Adriana G Arita, Francis P Lach, Thomas Landers, Melanie Wurm, Marcel Freund, Kornelia Neveling, Helmut Hanenberg, Arleen D Auerbach, Tony T Huang.   

Abstract

Activation of the Fanconi anemia (FA) DNA damage-response pathway results in the monoubiquitination of FANCD2, which is regulated by the nuclear FA core ubiquitin ligase complex. A FANCD2 protein sequence-based homology search facilitated the discovery of FANCI, a second monoubiquitinated component of the FA pathway. Biallelic mutations in the gene coding for this protein were found in cells from four FA patients, including an FA-I reference cell line.

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Year:  2007        PMID： 17460694     DOI： 10.1038/nsmb1252

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  144 in total

1.  Purification of FANCD2 sub-complexes.

Authors:  Gang Zhi; Xiaoyong Chen; William Newcomb; Jay Brown; Oliver J Semmes; Gary M Kupfer
Journal:  Br J Haematol       Date:  2010-04-29       Impact factor: 6.998

Review 2.  Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle.

Authors:  Xiomaris M Cotto-Rios; Mathew J K Jones; Tony T Huang
Journal:  Cell Cycle       Date:  2011-12-01       Impact factor: 4.534

3.  Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.

Authors:  Justin Wai Chung Leung; Yucai Wang; Ka Wing Fong; Michael Shing Yan Huen; Lei Li; Junjie Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-06       Impact factor: 11.205

4.  Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.

Authors:  Kalindi Parmar; Jungmin Kim; Stephen M Sykes; Akiko Shimamura; Patricia Stuckert; Kaya Zhu; Abigail Hamilton; Mary Kathryn Deloach; Jeffery L Kutok; Koichi Akashi; D Gary Gilliland; Alan D'andrea
Journal:  Stem Cells       Date:  2010-07       Impact factor: 6.277

5.  Replication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway.

Authors:  Seok-Won Jang; Jin Ki Jung; Jung Min Kim
Journal:  Cell Cycle       Date:  2016-07-11       Impact factor: 4.534

6.  Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair.

Authors:  Luca Colnaghi; Mathew J K Jones; Xiomaris M Cotto-Rios; Detlev Schindler; Helmut Hanenberg; Tony T Huang
Journal:  Blood       Date:  2010-10-22       Impact factor: 22.113

7.  UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.

Authors:  Arno Alpi; Frederic Langevin; Georgina Mosedale; Yuichi J Machida; Anindya Dutta; Ketan J Patel
Journal:  Mol Cell Biol       Date:  2007-10-15       Impact factor: 4.272

8.  FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair.

Authors:  Yutong Xue; Yongjiang Li; Rong Guo; Chen Ling; Weidong Wang
Journal:  Hum Mol Genet       Date:  2008-02-19       Impact factor: 6.150

9.  Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24.

Authors:  Jung Min Kim; Younghoon Kee; Allan Gurtan; Alan D D'Andrea
Journal:  Blood       Date:  2008-01-03       Impact factor: 22.113

Review 10.  FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress.

Authors:  Yuliang Wu; Robert M Brosh
Journal:  Curr Mol Med       Date:  2009-05       Impact factor: 2.222
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