Regulation of human life histories: the role of the inflammatory host response.

Most species with a long life span have few offspring while species with a short life span have many offspring. This evolutionary trade-off between fertility and body maintenance, based on the theory of r/K-selection, is a central theme in the theory of life history regulation. This trade-off is not only found between various species but also between individuals within one species. There is accumulating evidence for this trade-off in humans. We hypothesize that the innate immune system is a critical factor skewing an individual into the direction of either a high fertility or better maintenance strategy. As over thousands of years human survival has been highly dependent on resistance to infectious diseases, genetic adaptations resulting in inflammatory responses were favored. An inflammatory host response is critical to fight infection necessary to survive up to reproductive age. An inflammatory host response is also negatively associated with fertility and can explain for the trade-off between fertility and body maintenance. After human reproductive age, these inflammatory responses contribute also to development of chronic degenerative diseases. These will especially become apparent in affluent societies where the majority of individuals reach old age. Identifying the inflammatory host response as a critical factor both in the regulation of human life histories and in the occurrence of chronic diseases at old age implies means for intervention allowing individuals to live healthier for longer.