J Shi1, C B Zhao, T L Vollmer, T M Tyry, S M Kuniyoshi. 1. Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA. jiong.shi@chw.edu
Abstract
BACKGROUND: The role of apolipoprotein E (APOE) polymorphism has been well recognized in other cognitive neurodegenerative disorders, such as Alzheimer disease. Its role in multiple sclerosis (MS) is less clear, though studies indicate that 40% to 60% of patients with MS have evidence of cognitive impairment. OBJECTIVE: To determine whether there is an association between APOE epsilon 4 and cognitive deficits in MS. METHODS: We performed a standardized battery of neuropsychological tests investigating the four cognitive domains commonly impaired in MS and assessed the association of the presence of APOE epsilon 4 with cognition in MS. RESULTS: A strong association was found between the presence of APOE epsilon 4 and cognitive deficits in patients with MS, particularly in the domains of learning and memory. This association was strongest in our youngest cohort (age 31 to 40) of patients with MS. CONCLUSIONS: APOE epsilon 4 is significantly associated with cognitive impairment in patients with multiple sclerosis (MS). However, the modest effects do not justify APOE genotyping of patients with MS in clinical practice.
BACKGROUND: The role of apolipoprotein E (APOE) polymorphism has been well recognized in other cognitive neurodegenerative disorders, such as Alzheimer disease. Its role in multiple sclerosis (MS) is less clear, though studies indicate that 40% to 60% of patients with MS have evidence of cognitive impairment. OBJECTIVE: To determine whether there is an association between APOE epsilon 4 and cognitive deficits in MS. METHODS: We performed a standardized battery of neuropsychological tests investigating the four cognitive domains commonly impaired in MS and assessed the association of the presence of APOE epsilon 4 with cognition in MS. RESULTS: A strong association was found between the presence of APOE epsilon 4 and cognitive deficits in patients with MS, particularly in the domains of learning and memory. This association was strongest in our youngest cohort (age 31 to 40) of patients with MS. CONCLUSIONS:APOE epsilon 4 is significantly associated with cognitive impairment in patients with multiple sclerosis (MS). However, the modest effects do not justify APOE genotyping of patients with MS in clinical practice.
Authors: Linda Chang; Caroline Jiang; Eric Cunningham; Steven Buchthal; Vanessa Douet; Marilou Andres; Thomas Ernst Journal: Neurology Date: 2014-05-21 Impact factor: 9.910
Authors: Diana Morales; Summer F Acevedo; Richard L Skolasky; Rosa Hechavarria; Sharon Santiago; Tania De La Torre; Elizabeth Maldonado; Valerie Wojna Journal: J Neurovirol Date: 2012-09-13 Impact factor: 2.643