| Literature DB >> 17459809 |
Gianna Elena Hammer1, Takayuki Kanaseki, Nilabh Shastri.
Abstract
Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8(+) T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.Mesh：
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Year: 2007 PMID： 17459809 DOI： 10.1016/j.immuni.2007.04.003
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745