| Literature DB >> 17459804 |
Abstract
Secretion of the proinflammatory cytokine IL-1beta requires caspase-1 and Toll-like receptor (TLR) signaling. However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1beta precursor independently of TLRs.Entities:
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Year: 2007 PMID: 17459804 DOI: 10.1016/j.immuni.2007.04.005
Source DB: PubMed Journal: Immunity ISSN: 1074-7613 Impact factor: 31.745