| Literature DB >> 17459701 |
Qun Dang1, Yan Liu, Robert M Rydzewski, Brian S Brown, Edward Robinson, Paul D van Poelje, Timothy J Colby, Mark D Erion.
Abstract
A series of substituted bis[(para-methoxy)benzyl] (bisPMB) esters of 1-naphthalenemethylphosphonate (NMPA) were synthesized and evaluated as phosphonate prodrugs. BisPMB NMPA esters (4b and 4c) with significantly improved aqueous stability were identified that also resulted in increased intracellular levels of NMPA following prodrug incubation with primary rat hepatocytes.Entities:
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Year: 2007 PMID： 17459701 DOI： 10.1016/j.bmcl.2007.03.089
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823