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Literature DB >> 17459266

Testosterone replacement therapy and prostate cancer: a word of caution.

Timothy C Brand¹, Edith Canby-Hagino, Ian M Thompson.

Abstract

The number of men for whom testosterone is prescribed is rapidly increasing. The aging man normally demonstrates a gradual decline in testosterone. Symptoms of hypogonadism include erectile dysfunction, diminished libido, sarcopenia, increased adiposity, osteopenia and osteoporosis, impaired cognition, and depression. There is a paucity of data regarding both efficacy and safety of testosterone replacement therapy. Testosterone levels have been shown to modulate prostate cancer risk and progression. A prospective evaluation of prostate cancer risk with testosterone replacement therapy has not been conducted. We outline concerns and recommendations for the use of testosterone replacement therapy in the aging man.

Entities: Chemical Disease Species

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Year: 2007 PMID： 17459266 DOI： 10.1007/s11934-007-0004-x

Source DB: PubMed Journal: Curr Urol Rep ISSN： 1527-2737 Impact factor: 3.092

59 in total

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Journal: J Androl Date: 2002 May-Jun

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Journal: J Urol Date: 1990-12 Impact factor: 7.450

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Journal: Climacteric Date: 2002-03 Impact factor: 3.005

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Authors: Anthony J Swerdlow; Minouk J Schoemaker; Craig D Higgins; Alan F Wright; Patricia A Jacobs
Journal: J Natl Cancer Inst Date: 2005-08-17 Impact factor: 13.506

Review 8. An integrative review on current evidence of testosterone replacement therapy for the andropause.

Authors: Robert S Tan; John W Culberson
Journal: Maturitas Date: 2003-05-30 Impact factor: 4.342

9. Adenocarcinoma of the prostate in a 41-year-old man with XXY karyotype and chronic lymphocytic leukemia: report of a case.

Authors: E J Pienkos; L F Meisner
Journal: J Urol Date: 1991-01 Impact factor: 7.450

Testosterone replacement therapy and prostate cancer: a word of caution.

1. Long-term consequences of castration in men: lessons from the Skoptzy and the eunuchs of the Chinese and Ottoman courts.

Review 2. The aging male: testosterone deficiency and testosterone replacement. An up-date.

Review 3. Androgen deficiency and hormone-replacement therapy.

4. Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: a phase II study.

Review 5. Sudden death due to disease flare with luteinizing hormone-releasing hormone agonist therapy for carcinoma of the prostate.

Review 6. Defining 'relative' androgen deficiency in aging men: how should testosterone be measured and what are the relationships between androgen levels and physical, sexual and emotional health?

7. Cancer incidence and mortality in men with Klinefelter syndrome: a cohort study.

Review 8. An integrative review on current evidence of testosterone replacement therapy for the andropause.

9. Adenocarcinoma of the prostate in a 41-year-old man with XXY karyotype and chronic lymphocytic leukemia: report of a case.

10. Three-year follow-up of androgen treatment in hypogonadal men: preliminary report with testosterone gel.

1. Expression of an estrogen receptor agonist in differentiating osteoblast cultures.

2. Erectile dysfunction.

3. Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample.

4. Population-based patterns of prescription androgen use, 1976-2008.

5. Testosterone treatment is a potent tumor promoter for the rat prostate.

6. Sexual rehabilitation after localized prostate cancer: current interventions and future directions.