Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A mild and efficient synthesis of 4-quinolones and quinolone heterocycles.

Literature DB >> 17458997

A mild and efficient synthesis of 4-quinolones and quinolone heterocycles.

Daniel Zewge¹, Cheng-Yi Chen, Curtis Deer, Peter G Dormer, Dave L Hughes.

Abstract

The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditions than those traditionally employed. This cyclization protocol is used to prepare a host of heterocycles and bis-quinolones and is characterized by relatively low reaction temperature and ease of product isolation.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17458997 DOI： 10.1021/jo070181o

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

Keyword Cloud
Cited

11 in total

1. Total synthesis and absolute stereochemical assignment of kibdelone C.

Authors: David L Sloman; Jeffrey W Bacon; John A Porco
Journal: J Am Chem Soc Date: 2011-06-15 Impact factor: 15.419

2. Synthesis of polyfunctionalized acrylates via one-pot reactions of arylamines, methyl propiolate, aromatic aldehydes, and active methylene compounds.

Authors: Yan Sun; Jing Sun; Chao-Guo Yan
Journal: Mol Divers Date: 2011-11-30 Impact factor: 2.943

3. Synthesis of benzimidazole[2.1-b][1,3]oxazine spirooxindoles via three-component reaction of N-benzylbenzimidazole, acetylenedicarboxylates, and N-alkylisatins.

Authors: Li-Juan Zhang; Chao-Guo Yan
Journal: Mol Divers Date: 2014-08-19 Impact factor: 2.943

4. Phosphine-Initiated General-Base-Catalyzed Quinolone Synthesis.

Authors: San Khong; Ohyun Kwon
Journal: Asian J Org Chem Date: 2014-04 Impact factor: 3.319

5. P₄O₁₀/TfOH mediated domino condensation-cyclization of amines with diacids: a route to indolizidine alkaloids under catalyst- and solvent-free conditions.

Authors: Ketan S Mandrekar; Santosh G Tilve
Journal: RSC Adv Date: 2022-06-15 Impact factor: 4.036

6. A Green, Expeditious, One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature.

Authors: Amulrao Borse; Mahesh Patil; Nilesh Patil; Rohan Shinde
Journal: ISRN Org Chem Date: 2012-08-08

A mild and efficient synthesis of 4-quinolones and quinolone heterocycles.

1. Total synthesis and absolute stereochemical assignment of kibdelone C.

2. Synthesis of polyfunctionalized acrylates via one-pot reactions of arylamines, methyl propiolate, aromatic aldehydes, and active methylene compounds.

3. Synthesis of benzimidazole[2.1-b][1,3]oxazine spirooxindoles via three-component reaction of N-benzylbenzimidazole, acetylenedicarboxylates, and N-alkylisatins.

4. Phosphine-Initiated General-Base-Catalyzed Quinolone Synthesis.

5. P₄O₁₀/TfOH mediated domino condensation-cyclization of amines with diacids: a route to indolizidine alkaloids under catalyst- and solvent-free conditions.

6. A Green, Expeditious, One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature.

7. Design, synthesis, and biological evaluation of novel arylcarboxamide derivatives as anti-tubercular agents.

8. Easy-To-Access Quinolone Derivatives Exhibiting Antibacterial and Anti-Parasitic Activities.

9. An efficient access to the synthesis of novel 12-phenylbenzo[6,7]oxepino[3,4-b]quinolin-13(6H)-one derivatives.

10. A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines.