Literature DB >> 17458911

Pharmaceutical strategy and innovation: an academics perspective.

Ian R Baxendale1, John J Hayward, Steven V Ley, Geoffrey K Tranmer.   

Abstract

The pharmaceutical industry is under increasing pressure on many fronts, from investors requiring larger returns to consumer groups and health authorities demanding cheaper and safer drugs. It is also feeling additional pressure from the infringement upon its profit margins by generic drug producers. Many companies are aggressively pursuing outsourcing contracts in an attempt to counter many of the financial pressures and streamline their operations. At the same time, the productivity of the pharmaceutical industry at its science base is being questioned in terms of the number of products and the timeframes required for each company to deliver them to market. This has generated uncertainties regarding the current corporate strategies that have been adopted and the levels of innovation being demonstrated. In this essay we discuss these topics in the context of the global pharmaceutical market, investigating the basis for many of these issues and highlighting the hurdles the industry needs to overcome, especially as they relate to the chemical sciences.

Mesh:

Year:  2007        PMID: 17458911     DOI: 10.1002/cmdc.200700008

Source DB:  PubMed          Journal:  ChemMedChem        ISSN: 1860-7179            Impact factor:   3.466


  6 in total

1.  Rhinacanthin-C but Not -D Extracted from Rhinacanthus nasutus (L.) Kurz Offers Neuroprotection via ERK, CHOP, and LC3B Pathways.

Authors:  Varaporn Rakkhittawattana; Pharkphoom Panichayupakaranant; Mani I Prasanth; James M Brimson; Tewin Tencomnao
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-20

2.  Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters.

Authors:  Alessandro Palmieri; Steven V Ley; Anastasios Polyzos; Mark Ladlow; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2009-05-20       Impact factor: 2.883

3.  An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals.

Authors:  Marcus Baumann; Ian R Baxendale; Steven V Ley; Nikzad Nikbin
Journal:  Beilstein J Org Chem       Date:  2011-04-18       Impact factor: 2.883

Review 4.  An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles.

Authors:  Marcus Baumann; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2013-10-30       Impact factor: 2.883

5.  How Do Pharmaceutical Companies Overcome a Corporate Productivity Crisis? Business Diversification into Medical Devices for Growth Potential.

Authors:  Yoonje Euh; Daeho Lee
Journal:  Int J Environ Res Public Health       Date:  2021-01-25       Impact factor: 3.390

6.  Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression.

Authors:  James M Brimson; Kiran K Akula; Haider Abbas; David R Ferry; Shrinivas K Kulkarni; Steven T Russell; Michael J Tisdale; Tewin Tencomnao; Stephen T Safrany
Journal:  Sci Rep       Date:  2020-06-08       Impact factor: 4.379

  6 in total

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