Literature DB >> 17458843

Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.

James C Barrow1, Kenneth E Rittle, Phung L Ngo, Harold G Selnick, Samuel L Graham, Steven M Pitzenberger, Georgia B McGaughey, Dennis Colussi, Ming-Tain Lai, Qian Huang, Katherine Tugusheva, Amy S Espeseth, Adam J Simon, Sanjeev K Munshi, Joseph P Vacca.   

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Year:  2007        PMID： 17458843     DOI： 10.1002/cmdc.200700038

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  3 in total

Review 1.  BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.

Authors:  Arun K Ghosh; Heather L Osswald
Journal:  Chem Soc Rev       Date:  2014-10-07       Impact factor: 54.564

2.  Crystal structure, Hirshfeld surface analysis and PIXEL calculations of a 1:1 epimeric mixture of 3-[(4-nitro-benzyl-idene)amino]-2(R,S)-(4-nitro-phenyl)-5(S)-(propan-2-yl)imidazolidin-4-one.

Authors:  Ligia R Gomes; John Nicolson Low; James L Wardell; Marcus V N de Souza; Cristiane F da Costa
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-10-29

3.  Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors.

Authors:  Yiquan Zou; Li Li; Wuyan Chen; Tiantian Chen; Lanping Ma; Xin Wang; Bing Xiong; Yechun Xu; Jingkang Shen
Journal:  Molecules       Date:  2013-05-16       Impact factor: 4.411
  3 in total

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